Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | ATAD2 | Q6PL18 | 2/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.39 |
| ▸ | PAK4 | O96013 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | IGF1R | P08069 | 1/20 | 0.39 |
| ▸ | MET | P08581 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5244515 | 0.89 | ALOX5 (0.35) | RAB9AKDM4ETMPRSS2HTR1A | |
| SCHEMBL2312465 | 0.88 | HTR1A (0.43) | RAB9ASMN1; SMN2ALDH1A1HTR1AMEN1 | |
| SCHEMBL5242804 | 0.86 | NPC1 (0.35) | RAB9AKDM4ETMPRSS2HTR1A | |
| SCHEMBL4770219 | 0.82 | NPC1 (0.47) | RAB9AKDM4ESMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL4767049 | 0.81 | PKM (0.47) | RAB9AKDM4EPOLBROCK1SMN1; SMN2 | |
| SCHEMBL5556546 | 0.81 | RAB9A (0.43) | RAB9AKDM4EPOLBCHEK1AURKA | |
| SCHEMBL4637682 | 0.80 | NR1H2 (0.46) | ATAD2HTR1A | |
| SCHEMBL2124644 | 0.79 | ESR2 (0.45) | — | |
| SCHEMBL5170173 | 0.78 | ALDH1A1 (0.34) | KDM4ENAMPTALDH1A1MEN1KMT2A | |
| SCHEMBL19638276 | 0.78 | CAMK2A (0.41) | CAMK2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1751163-A2 | COMPOUNDS HAVING AFFINITY FOR DOPAMINE D3 RECEPTOR AND USES THEREOF | GLAXO GROUP LIMITED (GB) | 2007-02-14 | — | — | EP | disclosed |
| WO-2005118549-A2 | COMPOUNDS HAVING AFFINITY FOR DOPAMINE D3 RECEPTOR AND USES THEREOF | GLAXO GROUP LIMITED (GB) | 2005-12-15 | — | — | WO | disclosed |