Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | AKR1C3 | P42330 | 4/20 | 0.32 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.32 |
| ▸ | PPARG | P37231 | 7/20 | 0.32 |
| ▸ | PPARA | Q07869 | 3/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5560625 | 0.82 | MAPT (0.37) | KDM4ELMNASMN1; SMN2CNR2AKR1C3 | |
| SCHEMBL5560462 | 0.82 | PTGS2 (0.34) | ALOX15GFERADAM17KDM4EHTT | |
| SCHEMBL5558544 | 0.82 | PTGS2 (0.34) | ALOX15GFERADAM17KDM4EHTT | |
| SCHEMBL5559110 | 0.80 | MAOB (0.35) | AKR1C3AKR1C2 | |
| SCHEMBL5554445 | 0.75 | PPARG (0.37) | AKR1C3AKR1C2PPARGPPARA | |
| SCHEMBL5554636 | 0.72 | POLB (0.36) | ALOX15GFERADAM17LMNAAKR1C3 | |
| SCHEMBL5559588 | 0.72 | PTGS1 (0.36) | KDM4ELMNAAKR1C3AKR1C2PPARG | |
| SCHEMBL5559997 | 0.72 | PPARG (0.33) | ALOX15GFERADAM17LMNATSHR | |
| SCHEMBL27768503 | 0.72 | — | — | |
| SCHEMBL5799149 | 0.72 | AKR1C3 (0.43) | GAAKDM4ELMNACNR2AKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1643961-A4 | COX-2 AND FAAH INHIBITORS | MICROBIA INC (US) | 2007-09-12 | — | — | EP | disclosed |
| EP-1643961-A2 | COX-2 AND FAAH INHIBITORS | Microbia, Inc. (US) | 2006-04-12 | — | — | EP | disclosed |
| WO-2005002525-A2 | COX-2 AND FAAH INHIBITORS | MICROBIA, INC. (US) | 2005-01-13 | — | — | WO | disclosed |