Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 5/20 | 0.47 |
| ▸ | PRKACA | P17612 | 4/20 | 0.47 |
| ▸ | PRKACG | P22612 | 4/20 | 0.47 |
| ▸ | PRKACB | P22694 | 4/20 | 0.47 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 5/20 | 0.44 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.44 |
| ▸ | BCL2 | P10415 | 1/20 | 0.36 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | IGFBP3 | P17936 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5553811 | 0.89 | MAPT (0.40) | SRCPRKACAPRKACGPRKACBAKR1C3 | |
| SCHEMBL5558979 | 0.88 | AKR1C3 (0.39) | BCL2L1AKR1C3AKR1C2 | |
| SCHEMBL5560537 | 0.88 | AKR1C3 (0.47) | SRCPRKACAPRKACGPRKACBBCL2L1 | |
| SCHEMBL5800049 | 0.86 | KMT2A (0.37) | SRCAKR1C3AKR1C2KDM4EHSD17B10 | |
| SCHEMBL5821239 | 0.85 | AKR1C3 (0.38) | SRCPRKACAPRKACGPRKACBBCL2L1 | |
| SCHEMBL5823303 | 0.85 | AKR1C3 (0.43) | SRCPRKACAPRKACGPRKACBBCL2L1 | |
| SCHEMBL5559667 | 0.83 | PTGS2 (0.35) | SRCAKR1C3AKR1C2KDM4EHSD17B10 | |
| SCHEMBL5560264 | 0.83 | PTGS2 (0.35) | SRCAKR1C3AKR1C2HPGDKDM4E | |
| SCHEMBL5559414 | 0.83 | LMNA (0.40) | SRCAKR1C3AKR1C2HPGDKDM4E | |
| SCHEMBL5558391 | 0.82 | SRC (0.42) | SRCPRKACAPRKACGPRKACBBCL2L1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1643961-A4 | COX-2 AND FAAH INHIBITORS | MICROBIA INC (US) | 2007-09-12 | — | — | EP | disclosed |
| EP-1643961-A2 | COX-2 AND FAAH INHIBITORS | Microbia, Inc. (US) | 2006-04-12 | — | — | EP | disclosed |
| WO-2005002525-A2 | COX-2 AND FAAH INHIBITORS | MICROBIA, INC. (US) | 2005-01-13 | — | — | WO | disclosed |