Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 4/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.34 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.33 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | PREP | P48147 | 1/20 | 0.32 |
| ▸ | CELA1 | Q9UNI1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5559667 | 0.94 | PTGS2 (0.35) | PTGS2PTGS1AKR1C3AKR1C2SLC22A12 | |
| SCHEMBL5800049 | 0.88 | KMT2A (0.37) | PTGS2PTGS1AKR1C3AKR1C2SLC22A12 | |
| SCHEMBL5553811 | 0.87 | MAPT (0.40) | PTGS2HPGDAKR1C3AKR1C2KDM4E | |
| SCHEMBL5560588 | 0.86 | MAPT (0.39) | PTGS2AKR1C3AKR1C2KDM4ETP53 | |
| SCHEMBL5808410 | 0.86 | PTGS2 (0.35) | PTGS2PTGS1HPGDAKR1C3AKR1C2 | |
| SCHEMBL5559414 | 0.85 | LMNA (0.40) | HPGDAKR1C3AKR1C2TSHRKDM4E | |
| SCHEMBL6025591 | 0.84 | PTGS2 (0.48) | PTGS2PTGS1HPGDAKR1C3AKR1C2 | |
| SCHEMBL5558604 | 0.83 | SRC (0.47) | HPGDAKR1C3AKR1C2TSHRKDM4E | |
| SCHEMBL5561193 | 0.83 | HPGD (0.34) | PTGS2HPGDAKR1C3AKR1C2TSHR | |
| SCHEMBL5558979 | 0.81 | AKR1C3 (0.39) | AKR1C3AKR1C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1643961-A4 | COX-2 AND FAAH INHIBITORS | MICROBIA INC (US) | 2007-09-12 | — | — | EP | disclosed |
| EP-1643961-A2 | COX-2 AND FAAH INHIBITORS | Microbia, Inc. (US) | 2006-04-12 | — | — | EP | disclosed |
| WO-2005002525-A2 | COX-2 AND FAAH INHIBITORS | MICROBIA, INC. (US) | 2005-01-13 | — | — | WO | disclosed |