Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | CA2 | P00918 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | CA1 | P00915 | 3/20 | 0.36 |
| ▸ | EGFR | P00533 | 2/20 | 0.36 |
| ▸ | FYN | P06241 | 2/20 | 0.36 |
| ▸ | MMP9 | P14780 | 2/20 | 0.36 |
| ▸ | RECQL | P46063 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP8 | P22894 | 1/20 | 0.36 |
| ▸ | CA6 | P23280 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | MMP12 | P39900 | 1/20 | 0.36 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20819712 | 0.83 | ALDH1A1 (0.39) | ALDH1A1NPC1RAB9AMAPTMAPK1 | |
| SCHEMBL30603262 | 0.83 | ALDH1A1 (0.45) | ALDH1A1CA2LMNAHPGDALOX15 | |
| SCHEMBL7810681 | 0.79 | TRPA1 (0.34) | ALDH1A1CA2LMNAHPGDALOX15 | |
| SCHEMBL8414442 | 0.77 | CA1 (0.33) | ALDH1A1CA2LMNAHPGDALOX15 | |
| SCHEMBL9860862 | 0.74 | ALDH1A1 (0.38) | ALDH1A1CA2LMNAHPGDALOX15 | |
| SCHEMBL6943096 | 0.74 | IDO1 (0.35) | ALDH1A1 | |
| SCHEMBL24125843 | 0.73 | HSD11B1 (0.38) | ALDH1A1LMNAHPGDNPC1RAB9A | |
| SCHEMBL18796222 | 0.73 | LMNA (0.36) | ALDH1A1CA2LMNAHPGDALOX15 | |
| SCHEMBL31283290 | 0.73 | MAOB (0.33) | ALDH1A1LMNATDP1NPC1RAB9A | |
| SCHEMBL2636253 | 0.73 | MAOB (0.33) | ALDH1A1LMNATDP1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7304155-B2 | Tetrahydrobenzfluorene derivatives | N.V. ORGANON (NL) | 2007-12-04 | — | — | US | disclosed |
| US-20050119264-A1 | Tetrahydrobenzfluorene derivatives | MERCK SHARP & DOHME B.V. (NL) | 2005-06-02 | — | — | US | disclosed |
| EP-0601642-B1 | Photographic silver halide material and process | EASTMAN KODAK CO (US) | 1999-09-01 | — | — | EP | disclosed |
| EP-0601642-A1 | Photographic silver halide material and process | EASTMAN KODAK COMPANY (US) | 1994-06-15 | — | — | EP | disclosed |
| US-5306604-A | Dispersibility, low melting points | EASTMAN KODAK COMPANY (US) | 1994-04-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050119264-A1 | Tetrahydrobenzfluorene derivatives | ESR1, ESR2, GPER1 | ALDH1A1 1382/4885CA2 2581/4885LMNA 2534/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.