Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 8/20 | 0.48 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.42 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | PDE2A | O00408 | 2/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.37 |
| ▸ | CCND1 | P24385 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29907293 | 0.86 | TRPV4 (0.53) | MCL1TRPV4ALDH1A1L3MBTL1MEN1 | |
| SCHEMBL66378 | 0.86 | TRPV4 (0.53) | MCL1TRPV4ALDH1A1L3MBTL1MEN1 | |
| SCHEMBL25362679 | 0.83 | MCL1 (0.51) | MCL1TRPV4ALDH1A1L3MBTL1MEN1 | |
| SCHEMBL29707985 | 0.79 | SOD1 (0.47) | L3MBTL1MEN1TSHRKMT2ALMNA | |
| SCHEMBL152556 | 0.79 | SOD1 (0.47) | L3MBTL1MEN1TSHRKMT2ALMNA | |
| SCHEMBL3088227 | 0.78 | MCL1 (0.49) | MCL1TRPV4ALDH1A1L3MBTL1MEN1 | |
| SCHEMBL16770865 | 0.75 | MCL1 (0.47) | MCL1ALDH1A1L3MBTL1MEN1TSHR | |
| SCHEMBL2001719 | 0.74 | TRPV4 (0.50) | TRPV4ALDH1A1L3MBTL1 | |
| SCHEMBL29683114 | 0.73 | ALDH1A1 (0.59) | MCL1TRPV4ALDH1A1L3MBTL1MEN1 | |
| SCHEMBL67766 | 0.73 | ALDH1A1 (0.59) | MCL1TRPV4ALDH1A1L3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1610753-A4 | PHENYLENEDIAMINE UROTENSIN-II RECEPTOR ANTAGONISTS AND CCR-9 ANTAGONISTS | ENCYSIVE PHARMACEUTICALS INC (US) | 2007-07-04 | — | — | EP | disclosed |
| EP-1610753-A2 | PHENYLENEDIAMINE UROTENSIN-II RECEPTOR ANTAGONISTS AND CCR-9 ANTAGONISTS | ENCYSIVE PHARMACEUTICALS INC. (US) | 2006-01-04 | — | — | EP | disclosed |
| WO-2004073634-A2 | PHENYLENEDIAMINE UROTENSIN-II RECEPTOR ANTAGONISTS AND CCR-9 ANTAGONISTS | ENCYSIVE PHARMACEUTICALS INC. (US) | 2004-09-02 | — | — | WO | disclosed |