SCHEMBL29907293

SCHEMBL29907293

O=S(=O)(Cl)c1ccc(C(F)(F)F)cc1Cl

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TRPV4 Q9HBA0 3/20 0.53
MEN1 O00255 1/20 0.47
ALDH1A1 P00352 1/20 0.47
TSHR P16473 1/20 0.47
KMT2A Q03164 1/20 0.47
ATM Q13315 1/20 0.47
L3MBTL1 Q9Y468 1/20 0.47
MCL1 Q07820 8/20 0.45
CDK1 P06493 1/20 0.45
CCNB1 P14635 1/20 0.45
CCNA2 P20248 1/20 0.45
CCND1 P24385 1/20 0.45
CDK2 P24941 1/20 0.45
CDK7 P50613 1/20 0.45
CCNH P51946 1/20 0.45
CCNA1 P78396 1/20 0.45
CDK6 Q00534 1/20 0.45
PDE2A O00408 2/20 0.43
KIF11 P52732 1/20 0.43
HSD11B1 P28845 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL66378 1.00 TRPV4 (0.53) TRPV4MEN1ALDH1A1TSHRKMT2A
SCHEMBL5559314 0.86 MCL1 (0.48) TRPV4MEN1ALDH1A1TSHRKMT2A
SCHEMBL67766 0.85 ALDH1A1 (0.59) TRPV4MEN1ALDH1A1TSHRKMT2A
SCHEMBL29683114 0.85 ALDH1A1 (0.59) TRPV4MEN1ALDH1A1TSHRKMT2A
SCHEMBL16770865 0.83 MCL1 (0.47) MEN1ALDH1A1TSHRKMT2AATM
SCHEMBL27855832 0.83 MRGPRX4 (0.47) TRPV4MEN1ALDH1A1TSHRKMT2A
SCHEMBL6038959 0.83 KIF11 (0.49) MEN1ALDH1A1TSHRKMT2AATM
SCHEMBL6038948 0.83 MEN1 (0.46) TRPV4MEN1ALDH1A1TSHRKMT2A
SCHEMBL2001719 0.82 TRPV4 (0.50) TRPV4ALDH1A1L3MBTL1HSD11B1
Hydrochloric Acid SCHEMBL28078954 0.81 MRGPRX4 (0.46) TRPV4MEN1ALDH1A1TSHRKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119118894-A TRPV4 receptor ligands 犹他大学研究基金会 2024-12-13 CN disclosed
EP-4326719-A1 PYRIDO[3,2-D]PYRIMIDINE COMPOUNDS USES THEREOF FOR TREATING A PROLIFERATIVE DISEASE Université de Montréal (CA) 2024-02-28 EP disclosed
EP-4326723-A1 PYRIMIDO[5,4,D]PYRIMIDINE COMPOUNDS, COMPOSITIONS COMPRISING THEM AND USES THEREOF Université de Montréal (CA) 2024-02-28 EP disclosed
WO-2022221939-A1 PYRIDO[3,2-D]PYRIMIDINE COMPOUNDS USES THEREOF FOR TREATING A PROLIFERATIVE DISEASE UNIVERSITE DE MONTREAL (CA) 2022-10-27 WO disclosed
WO-2022221940-A1 PYRIMIDO[5,4,D]PYRIMIDINE COMPOUNDS, COMPOSITIONS COMPRISING THEM AND USES THEREOF UNIVERSITE DE MONTREAL (CA) 2022-10-27 WO disclosed
EP-4061124-A1 TRPV4 RECEPTOR LIGANDS University of Utah Research Foundation (US) 2022-09-28 EP disclosed
CN-115052478-A TRPV4 receptor ligands 犹他大学研究基金会 2022-09-13 CN disclosed