Sugi Predict

Sugi Predict / Compounds / SCHEMBL67766

SCHEMBL67766

SCHEMBL67766

O=S(=O)(Cl)c1cc(C(F)(F)F)ccc1Cl

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 2/20 0.59
▸ L3MBTL1 Q9Y468 2/20 0.59
▸ MEN1 O00255 1/20 0.59
▸ TSHR P16473 1/20 0.59
▸ KMT2A Q03164 1/20 0.59
▸ ATM Q13315 1/20 0.59
▸ MCL1 Q07820 8/20 0.53
▸ LMNA P02545 1/20 0.49
▸ GLA P06280 1/20 0.49
▸ HSD11B1 P28845 1/20 0.48
▸ CDK1 P06493 1/20 0.42
▸ CCNB1 P14635 1/20 0.42
▸ CCNA2 P20248 1/20 0.42
▸ CCND1 P24385 1/20 0.42
▸ CDK2 P24941 1/20 0.42
▸ CDK7 P50613 1/20 0.42
▸ CCNH P51946 1/20 0.42
▸ CCNA1 P78396 1/20 0.42
▸ CDK6 Q00534 1/20 0.42
▸ RAB9A P51151 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29683114 1.00 ALDH1A1 (0.59) ALDH1A1L3MBTL1MEN1TSHRKMT2A
SCHEMBL66378 0.85 TRPV4 (0.53) ALDH1A1L3MBTL1MEN1TSHRKMT2A
SCHEMBL29907293 0.85 TRPV4 (0.53) ALDH1A1L3MBTL1MEN1TSHRKMT2A
SCHEMBL27855804 0.83 ALDH1A1 (0.58) ALDH1A1L3MBTL1MEN1TSHRKMT2A
SCHEMBL16555634 0.83 ALDH1A1 (0.58) ALDH1A1L3MBTL1MEN1TSHRKMT2A
SCHEMBL2725140 0.83 ALDH1A1 (0.58) ALDH1A1L3MBTL1MEN1TSHRKMT2A
SCHEMBL10540391 0.82 HSD11B1 (0.47) ALDH1A1L3MBTL1MEN1TSHRKMT2A
SCHEMBL30161533 0.81 TRPV4 (0.47) ALDH1A1L3MBTL1MEN1TSHRKMT2A
SCHEMBL941069 0.81 TRPV4 (0.47) ALDH1A1L3MBTL1MEN1TSHRKMT2A
SCHEMBL30161606 0.81 MEN1 (0.44) ALDH1A1L3MBTL1MEN1TSHRKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 192 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1377589-B1 OXAZOLYL-PYRAZOLE DERIVATIVES AS KINASE INHIBITORS PHARMACIA ITALIA SPA (IT) 2005-09-07 — — EP claimed
US-4797484-A REACTING GUANIDINE DERIVATIVE WITH SULPHONYL HALIDE BAYER AKTIENGESELLSCHAFT (DE) 1989-01-10 — — US claimed
EP-3498693-B1 HETEROCYCLIC COMPOUND TAKEDA PHARMACEUTICALS CO (JP) 2024-10-30 — — EP disclosed
US-11433061-B2 Heteroaryl sulfonamides and CCR2/CCR9 CHEMOCENTRYX, INC. (US) 2022-09-06 — — US disclosed
CN-109790122-B Heterocyclic compounds 武田药品工业株式会社 2022-06-24 — — CN disclosed
US-10968232-B2 Antidiabetic spirochroman compounds MERCK SHARP & DOHME CORP. (US) 2021-04-06 — — US disclosed
US-10696651-B2 Heterocyclic compound TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2020-06-30 — — US disclosed
US-20200147066-A1 Heteroaryl Sulfonamides and CCR2/CCR9 CHEMOCENTRYX, INC. 2020-05-14 — — US disclosed
US-20190337961-A1 ANTIDIABETIC SPIROCHROMAN COMPOUNDS MERCK SHARP & DOHME CORP. (US) 2019-11-07 — — US disclosed
EP-3558298-A1 ANTIDIABETIC SPIROCHROMAN COMPOUNDS Merck Sharp & Dohme Corp. (US) 2019-10-30 — — EP disclosed
EP-3498693-A1 HETEROCYCLIC COMPOUND Takeda Pharmaceutical Company Limited (JP) 2019-06-19 — — EP disclosed
EP-0193390-B1 AN N-(2-CHLORO-4-TRIFLUOROMETHYLPHENYL)-3-TRIFLUOROMETHYL-BENZENESULFONAMIDE DERIVATIVE, PROCESS OF PREPARING IT AND AGRICULTURAL FUNGICIDE CONTAINING IT MITSUI TOATSU CHEMICALS, Inc. (JP) 1988-05-04 — — EP disclosed
US-4725305-A PLANT GROWTH REGULATORS BAYER AKTIENGESELLSCHAFT (DE) 1988-02-16 — — US disclosed
US-4725303-A N'-(substituted-pyrimidin-2-yl)-N\"-amino-N\"'-(substituted-benzenesulphonyl)-guanidines as herbicides BAYER AKTIENGESELLSCHAFT (DE) 1988-02-16 — — US disclosed
US-4721785-A FOR THE 2-GUANIDINE DERIVATIVE HERBICIDE PRODUCTS BAYER AKTIENGESELLSCHAFT (DE) 1988-01-26 — — US disclosed
US-4692466-A N-(2-chloro-4-trifluoromethylphenyl)-3-trifluoromethylbenzenesulfonamide derivative and agricultural fungicide containing same MITSUI TOATSU CHEMICALS, INCORPORATED (JP) 1987-09-08 — — US disclosed
EP-0193390-A1 An n-(2-chloro-4-trifluoromethylphenyl)-3-trifluoromethyl-benzenesulfonamide derivative, process of preparing it and agricultural fungicide containing it MITSUI TOATSU CHEMICALS, Inc. (JP) 1986-09-03 — — EP disclosed
US-4602938-A N'-(substituted-pyrimidin-2-yl)-N\"-substituted-N\",N\"'-bis-(substituted-benzenesulphonyl)-guanidines as herbicides BAYER AKTIENGESELLSCHAFT (DE) 1986-07-29 — — US disclosed
US-4507315-A Hypoglycaemic and hypolipidaemic benzamide substituted (1H-) imidazole derivatives and compositions MAY & BAKER LIMITED (GB) 1985-03-26 — — US disclosed
EP-0121082-A1 Guanidin derivatives BAYER AG (DE) 1984-10-10 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11433061-B2 Heteroaryl sulfonamides and CCR2/CCR9 CCR2, CCR9, CCR1 ALDH1A1 2834/4885L3MBTL1 2669/4885MEN1 4873/4885
US-10696651-B2 Heterocyclic compound EIF2AK4, GCN1, GTF2I ALDH1A1 3548/4885L3MBTL1 2725/4885MEN1 415/4885
US-10968232-B2 Antidiabetic spirochroman compounds GPR119, GPR52, GPR55 ALDH1A1 1981/4885L3MBTL1 4463/4885MEN1 3103/4885
US-20190337961-A1 ANTIDIABETIC SPIROCHROMAN COMPOUNDS GPR119, GPR52, GPR55 ALDH1A1 1981/4885L3MBTL1 4463/4885MEN1 3103/4885
US-20200147066-A1 Heteroaryl Sulfonamides and CCR2/CCR9 CCR2, CCR9, CCR1 ALDH1A1 2834/4885L3MBTL1 2669/4885MEN1 4873/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.