Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.32 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.32 |
| ▸ | TACR3 | P29371 | 5/20 | 0.31 |
| ▸ | TACR2 | P21452 | 4/20 | 0.31 |
| ▸ | TACR1 | P25103 | 3/20 | 0.31 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.31 |
| ▸ | RORC | P51449 | 1/20 | 0.31 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.30 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.30 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.30 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.30 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.30 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.30 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5800435 | 0.88 | MAOB (0.35) | MAOBAKR1C3AKR1C2PTGS2TACR3 | |
| SCHEMBL5560487 | 0.81 | PDE2A (0.37) | MAOBAKR1C3AKR1C2PTGS2TACR3 | |
| SCHEMBL5560527 | 0.81 | PTGS2 (0.33) | MAOBAKR1C3AKR1C2PTGS2PTGS1 | |
| SCHEMBL5800516 | 0.81 | ABCB11 (0.35) | AKR1C3AKR1C2PTGS2SLC22A12PTGS1 | |
| SCHEMBL5554202 | 0.81 | TACR3 (0.33) | MAOBAKR1C3AKR1C2PTGS2TACR3 | |
| SCHEMBL5560927 | 0.80 | GAA (0.35) | AKR1C3AKR1C2 | |
| SCHEMBL5559667 | 0.79 | PTGS2 (0.35) | MAOBAKR1C3AKR1C2PTGS2TACR3 | |
| SCHEMBL5800412 | 0.79 | PTGS2 (0.46) | MAOBAKR1C3AKR1C2PTGS2PTGS1 | |
| SCHEMBL5553743 | 0.75 | AKR1C3 (0.35) | MAOBAKR1C3AKR1C2PTGS2SLC22A12 | |
| SCHEMBL6464344 | 0.75 | AKR1C3 (0.35) | MAOBAKR1C3AKR1C2PTGS2TACR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1643961-A4 | COX-2 AND FAAH INHIBITORS | MICROBIA INC (US) | 2007-09-12 | — | — | EP | disclosed |
| EP-1643961-A2 | COX-2 AND FAAH INHIBITORS | Microbia, Inc. (US) | 2006-04-12 | — | — | EP | disclosed |
| WO-2005002525-A2 | COX-2 AND FAAH INHIBITORS | MICROBIA, INC. (US) | 2005-01-13 | — | — | WO | disclosed |