Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 5/20 | 0.36 |
| ▸ | CDK4 | P11802 | 3/20 | 0.35 |
| ▸ | CCND1 | P24385 | 3/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL557041 | 0.82 | FFAR1 (0.37) | KDM4EALDH1A1KMT2AHPGDFFAR1 | |
| SCHEMBL31064494 | 0.80 | FFAR1 (0.52) | FFAR1 | |
| SCHEMBL534744 | 0.73 | MTNR1A (0.51) | KMT2AMEN1CYP1A2TSHRCYP2C19 | |
| SCHEMBL16333188 | 0.72 | HTR1A (0.54) | KMT2ACDK4CCND1CDK2NPC1 | |
| SCHEMBL20945362 | 0.72 | KDM4E (0.43) | KDM4EALDH1A1KMT2AMEN1CYP1A2 | |
| SCHEMBL29791106 | 0.72 | KDM4E (0.43) | KDM4EALDH1A1KMT2AMEN1CYP1A2 | |
| SCHEMBL15524054 | 0.72 | KDM4E (0.38) | KDM4EALDH1A1KMT2AMEN1CYP1A2 | |
| SCHEMBL18422574 | 0.71 | TAAR1 (0.62) | ALDH1A1KMT2AMEN1CDK4CCND1 | |
| SCHEMBL555604 | 0.71 | TAAR1 (0.62) | KDM4EALDH1A1KMT2AMEN1HPGD | |
| SCHEMBL27759121 | 0.71 | SIGMAR1 (0.47) | KDM4EALDH1A1KMT2AHPGDCDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120035214-A1 | RENIN INHIBITORS | MERCK CANADA INC. (CA) | 2012-02-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120035214-A1 | RENIN INHIBITORS | REN, ACE, AGTR1 | KDM4E 2653/4885ALDH1A1 900/4885KMT2A 3390/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.