Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.48 |
| ▸ | NPC1 | O15118 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5565742 | 0.90 | KDM4E (0.46) | KDM4ENPC1RAB9AALDH1A1MAPT | |
| SCHEMBL6455153 | 0.81 | ALDH1A1 (0.50) | KDM4EALDH1A1MAPTL3MBTL1NPSR1 | |
| SCHEMBL6462245 | 0.81 | KDM4E (0.45) | KDM4ENPC1RAB9AALDH1A1MAPT | |
| SCHEMBL6454902 | 0.80 | ALDH1A1 (0.46) | KDM4EALDH1A1MAPTTDP1HSD17B10 | |
| SCHEMBL5557107 | 0.79 | NPSR1 (0.43) | ALDH1A1MAPTTDP1HSD17B10L3MBTL1 | |
| SCHEMBL5564443 | 0.79 | NPSR1 (0.46) | ALDH1A1MAPTL3MBTL1NPSR1ATM | |
| SCHEMBL5561977 | 0.75 | ALDH1A1 (0.56) | ALDH1A1MAPTSLC6A3L3MBTL1NPSR1 | |
| SCHEMBL5565065 | 0.75 | NPSR1 (0.42) | KDM4ERAB9AMAPTL3MBTL1NPSR1 | |
| SCHEMBL5560541 | 0.75 | SENP1 (0.43) | NPC1RAB9AALDH1A1MAPTL3MBTL1 | |
| SCHEMBL5559856 | 0.74 | NPSR1 (0.40) | KDM4EALDH1A1MAPTL3MBTL1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778683-A1 | THIOPHENE DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-05-02 | — | — | EP | disclosed |
| WO-2005121134-A1 | THIOPHENE DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-12-22 | — | — | WO | disclosed |