Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | TACR1 | P25103 | 3/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | BCR | P11274 | 1/20 | 0.33 |
| ▸ | TACR3 | P29371 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL556872 | 0.89 | NR1H2 (0.37) | CYP1A2POLBCYP3A4CYP2C19NR1H2 | |
| SCHEMBL556462 | 0.82 | PDE4B (0.43) | CYP1A2POLBCYP3A4CYP2C19NR1H2 | |
| SCHEMBL557595 | 0.81 | PDE4B (0.43) | CYP1A2POLBCYP3A4CYP2C19NR1H2 | |
| SCHEMBL29481460 | 0.73 | TACR1 (0.43) | NR1H2NR1H3NTRK1DPP4PDE4B | |
| SCHEMBL23013151 | 0.73 | TACR1 (0.43) | NR1H2NR1H3NTRK1DPP4PDE4B | |
| SCHEMBL556953 | 0.73 | KDM1A (0.37) | HTR2AHTR2CHTR2B | |
| SCHEMBL19271005 | 0.72 | PDE4B (0.51) | DPP4PDE4BTACR1USP30RORC | |
| SCHEMBL19270998 | 0.72 | PDE4B (0.50) | DPP4PDE4BTACR1USP30RORC | |
| SCHEMBL13093181 | 0.69 | NTRK1 (0.40) | NR1H2NR1H3NTRK1DPP4PDE4B | |
| SCHEMBL5158474 | 0.69 | DPP4 (0.47) | DPP4PDE4BTACR1USP30RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120035214-A1 | RENIN INHIBITORS | MERCK CANADA INC. (CA) | 2012-02-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120035214-A1 | RENIN INHIBITORS | REN, ACE, AGTR1 | CYP1A2 456/4885POLB 1555/4885CYP3A4 766/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.