Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.39 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.39 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.39 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.39 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | PER2 | O15055 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30345199 | 0.72 | GPX4 (0.40) | CACNA2D1CACNA1BCACNB1CACNA1CCYP2D6 | |
| SCHEMBL9815074 | 0.71 | PER2 (0.47) | PER2MAPTALDH1A1 | |
| SCHEMBL5013369 | 0.71 | CACNA2D1 (0.64) | CACNA1HCACNA2D1CACNA1BCACNB1CACNA1C | |
| SCHEMBL5543969 | 0.67 | CACNA2D1 (0.57) | KMT2AMEN1CACNA2D1CACNA1BCACNB1 | |
| SCHEMBL6580284 | 0.67 | CYP3A4 (0.47) | KMT2AMEN1NPC1L3MBTL1POLB | |
| SCHEMBL17360649 | 0.66 | KMT2A (0.41) | KMT2AMEN1L3MBTL1POLBCYP2D6 | |
| SCHEMBL5563143 | 0.65 | KMT2A (0.48) | KMT2AMEN1CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL22148074 | 0.64 | SLC6A9 (0.42) | KMT2APER2L3MBTL1CYP2D6OPRM1 | |
| SCHEMBL14600365 | 0.63 | KMT2A (0.55) | KMT2AMEN1PER2L3MBTL1POLB | |
| SCHEMBL7454329 | 0.63 | POLB (0.55) | KMT2AMEN1L3MBTL1POLBCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0819123-B1 | 1,3-DIHYDRO-1-(PHENYLALKENYL)-2H-IMIDAZOL-2-ONE DERIVATIVES HAVING PDE IV AND CYTOKINE INHIBITING ACTIVITY | JANSSEN PHARMACEUTICA NV (BE) | 2007-12-12 | — | — | EP | disclosed |
| US-5952510-A | ENZYME INHIBITOR AS ANTIALLERGENS, ANTIINFLAMMATORY AGENT TREATING INFLAMMATION DISEASES, SKIN DISORDERS | JANSSEN PHARMACEUTICA, N.V. (BG) | 1999-09-14 | — | — | US | disclosed |
| EP-0819123-A1 | 1,3-DIHYDRO-1-(PHENYLALKENYL)-2H-IMIDAZOL-2-ONE DERIVATIVES HAVING PDE IV AND CYTOKINE INHIBITING ACTIVITY | JANSSEN PHARMACEUTICA N.V. (BE) | 1998-01-21 | — | — | EP | disclosed |
| WO-1996031486-A1 | 1,3-DIHYDRO-1-(PHENYLALKENYL)-2H-IMIDAZOL-2-ONE DERIVATIVES HAVING PDE IV AND CYTOKINE INHIBITING ACTIVITY | JANSSEN PHARMACEUTICA N.V. (BE) | 1996-10-10 | — | — | WO | disclosed |