Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 4/20 | 0.46 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.46 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.43 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10476140 | 0.89 | TBXAS1 (0.49) | — | |
| SCHEMBL27780460 | 0.84 | CHRNB2 (0.46) | CHRNB2CHRNA4NAPRTCYP1A2CYP2D6 | |
| SCHEMBL1162017 | 0.83 | CHRNA7 (0.49) | CHRNB2CHRNA4CYP1A2CYP2D6CHRNA7 | |
| SCHEMBL28923713 | 0.82 | NAPRT (0.49) | NAPRTCYP1A2CYP2D6CHRNA7TDP1 | |
| Methanesulfonic Acid Ethyl Ester SCHEMBL4022952 | 0.81 | ALDH1A1 (0.47) | CHRNB2CHRNA4NAPRTTDP1L3MBTL1 | |
| SCHEMBL7497919 | 0.80 | TDP1 (0.54) | CYP2D6CHRNA7TDP1L3MBTL1 | |
| SCHEMBL4510112 | 0.78 | NAMPT (0.52) | NAPRTTDP1NAMPTPDE4APDE4B | |
| SCHEMBL30612269 | 0.78 | PKM (0.49) | CYP2D6NAMPT | |
| SCHEMBL8075924 | 0.78 | PKM (0.49) | CYP2D6NAMPT | |
| SCHEMBL507343 | 0.78 | KMT2A (0.48) | TDP1L3MBTL1NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-7291965-A | — | — | None | — | — | JP | disclosed |
| JP-8012670-A | — | — | None | — | — | JP | disclosed |
| EP-2419427-B1 | BICYCLIC HETEROCYCLYL DERIVATIVES AS FGFR KINASE INHIBITORS FOR THERAPEUTIC USE | ASTEX THERAPEUTICS LTD (GB) | 2016-04-06 | — | — | EP | disclosed |
| CN-104370804-A | Substituted methylamine compound preparation method | NIPPON SODA CO | 2015-02-25 | — | — | CN | disclosed |
| US-8481531-B2 | Bicyclic heterocyclyl derivatives as FGFR kinase inhibitors for therapeutic use | ASTEX THERAPEUTICS LTD (GB) | 2013-07-09 | — | — | US | disclosed |
| CN-101253164-B | Indole-3-carbonyl-spiro-piperidine derivatives as V1a receptor antagonists | HOFFMANN LA ROCHE | 2012-05-16 | — | — | CN | disclosed |
| US-20120035171-A1 | BICYCLIC HETEROCYCLYL DERIVATIVES AS FGFR KINASE INHIBITORS FOR THERAPEUTIC USE | ASTEX THERAPEUTICS LIMITED (GB) | 2012-02-09 | — | — | US | disclosed |
| US-7776900-B2 | Benzimidazole derivatives and their use for modulating the GABAAreceptor complex | NEUROSEARCH A/S (DK) | 2010-08-17 | — | — | US | disclosed |
| CN-101652347-A | Process for producing substituted methylamine compound and triazine derivative | NIPPON SODA CO JP | 2010-02-17 | — | — | CN | disclosed |
| US-7629353-B2 | Indol-3-yl-carbonyl-spiro-piperidine derivatives as V1a receptor antagonists | HOFFMAN-LA ROCHE INC. (US) | 2009-12-08 | — | — | US | disclosed |
| US-7332501-B2 | Indol-3-yl-carbonyl-spiro-piperidine derivatives as V1a receptor antagonists | HOFFMANN-LA ROCHE INC. (US) | 2008-02-19 | — | — | US | disclosed |
| US-20070099961-A1 | Method for producing bactericidal pyridine compound and bactericidal pyridine compound | Kourai, Hiroki (JP) | 2007-05-03 | — | — | US | disclosed |
| US-20070027173-A1 | Indol-3-yl-carbonyl-spiro-piperidine derivatives as Vla receptor antagonists | F. HOFFMANN-LA ROCHE AG (CH) | 2007-02-01 | — | — | US | disclosed |
| WO-2007006688-A1 | INDOL-3-CARBONYL-SPIRO-PIPERIDINE DERIVATIVES AS V1A RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-01-18 | — | — | WO | disclosed |
| EP-1683787-A1 | METHOD FOR PRODUCING BACTERICIDAL PYRIDINE COMPOUND AND BACTERICIDAL PYRIDINE COMPOUND | Tama Kagaku Kogyo Co., Ltd. (JP) | 2006-07-26 | — | — | EP | disclosed |
| JP-H0812670-A | NEW PYRROLIDINE DERIVATIVE | KISSEI PHARMACEUT CO LTD | 1996-01-16 | — | — | JP | disclosed |
| JP-H07291965-A | NOVEL PYRROLIDINE DERIVATIVE | KISSEI PHARMACEUT CO LTD | 1995-11-07 | — | — | JP | disclosed |
| EP-0297621-B1 | Cyclic amino-thioacetal amides, a process for the preparation thereof and pharmaceutical compositions containing them | BOEHRINGER MANNHEIM ITALIA (IT) | 1994-09-21 | — | — | EP | disclosed |
| US-4988701-A | Cyclic amino-thioacetal amides, a process for the preparation thereof and pharmaceutical compositions | BOEHRINGER BIOCHEMIA ROBIN S.P.A. (IT) | 1991-01-29 | — | — | US | disclosed |
| EP-0297621-A2 | Cyclic amino-thioacetal amides, a process for the preparation thereof and pharmaceutical compositions containing them | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1989-01-04 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070027173-A1 | Indol-3-yl-carbonyl-spiro-piperidine derivatives as Vla receptor antagonists | AVPR1A, AVPR2, AVPR1B | CHRNB2 2130/4885CHRNA4 997/4885NAPRT 3446/4885 |
| US-20070099961-A1 | Method for producing bactericidal pyridine compound and bactericidal pyridine compound | BLVRB, CBR3, TLR7 | CHRNB2 4084/4885CHRNA4 4153/4885NAPRT 2474/4885 |
| US-20120035171-A1 | BICYCLIC HETEROCYCLYL DERIVATIVES AS FGFR KINASE INHIBITORS FOR THERAPEUTIC USE | FGFR1, FGFR2, FGFR3 | CHRNB2 4834/4885CHRNA4 4872/4885NAPRT 942/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.