Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.63 |
| ▸ | HTR2A | P28223 | 2/20 | 0.62 |
| ▸ | HTR2C | P28335 | 2/20 | 0.62 |
| ▸ | HTR2B | P41595 | 2/20 | 0.62 |
| ▸ | TUBB4A | P04350 | 3/20 | 0.57 |
| ▸ | TUBB | P07437 | 3/20 | 0.57 |
| ▸ | TUBA3C | P0DPH7 | 3/20 | 0.57 |
| ▸ | TUBA1B | P68363 | 3/20 | 0.57 |
| ▸ | TUBA4A | P68366 | 3/20 | 0.57 |
| ▸ | TUBB4B | P68371 | 3/20 | 0.57 |
| ▸ | TUBB3 | Q13509 | 3/20 | 0.57 |
| ▸ | TUBB2A | Q13885 | 3/20 | 0.57 |
| ▸ | TUBB8 | Q3ZCM7 | 3/20 | 0.57 |
| ▸ | TUBA3E | Q6PEY2 | 3/20 | 0.57 |
| ▸ | TUBA1A | Q71U36 | 3/20 | 0.57 |
| ▸ | TUBA1C | Q9BQE3 | 3/20 | 0.57 |
| ▸ | TUBB6 | Q9BUF5 | 3/20 | 0.57 |
| ▸ | TUBB2B | Q9BVA1 | 3/20 | 0.57 |
| ▸ | TUBB1 | Q9H4B7 | 3/20 | 0.57 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5514786 | 0.94 | PTGS2 (0.61) | PTGS2HTR2AHTR2CHTR2BTUBB4A | |
| SCHEMBL10772012 | 0.92 | PTGS2 (0.59) | PTGS2HTR2AHTR2CHTR2BTUBB4A | |
| SCHEMBL10774727 | 0.92 | PTGS2 (0.59) | PTGS2HTR2AHTR2CHTR2BTUBB4A | |
| SCHEMBL10773005 | 0.92 | PTGS2 (0.59) | PTGS2HTR2AHTR2CHTR2BTUBB4A | |
| SCHEMBL7424861 | 0.89 | HTR2A (0.69) | PTGS2HTR2AHTR2CHTR2BTUBB4A | |
| SCHEMBL2500546 | 0.87 | PTGS2 (0.68) | PTGS2HTR2AHTR2CHTR2BTUBB4A | |
| SCHEMBL4464142 | 0.84 | HTR2A (0.75) | PTGS2HTR2AHTR2CHTR2BTUBB4A | |
| SCHEMBL10355755 | 0.82 | PPARA (0.59) | PTGS2HTR2AHTR2CHTR2BTUBB4A | |
| SCHEMBL900845 | 0.82 | HTR2A (0.60) | PTGS2HTR2AHTR2CHTR2BTUBB4A | |
| SCHEMBL2007007 | 0.82 | TNKS2 (0.68) | PTGS2HTR2AHTR2CHTR2BTUBB4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2925319-B1 | MIXED LINEAGE KINASE INHIBITORS FOR HIV/AIDS THERAPIES | UNIV ROCHESTER (US) | 2019-01-09 | — | — | EP | disclosed |
| CN-105237460-B | 2-acyl group replaces the one-step method for synthesizing of 1-isoindolinone compounds | 陕西师范大学 | 2016-08-17 | — | — | CN | disclosed |
| US-8778941-B2 | TRPM8 antagonists and their use in treatments | AMGEN INC. (US) | 2014-07-15 | — | — | US | disclosed |
| US-20130158034-A1 | TRPM8 ANTAGONISTS AND THEIR USE IN TREATMENTS | AMGEN INC. (US) | 2013-06-20 | — | — | US | disclosed |
| US-7868204-B2 | Inhibitors of histone deacetylase | METHYLGENE INC. (CA) | 2011-01-11 | — | — | US | disclosed |
| US-7868205-B2 | Inhibitors of histone deacetylase | METHYLGENE INC. (CA) | 2011-01-11 | — | — | US | disclosed |
| US-7838520-B2 | Inhibitors of histone deacetylase | METHYLGENE, INC. (CA) | 2010-11-23 | — | — | US | disclosed |
| US-7595343-B2 | Inhibitors of histone deacetylase | METHYLGENE, INC. (CA) | 2009-09-29 | — | — | US | disclosed |
| US-20080132459-A1 | Inhibitors of Histone Deacetylase | METHYLGENE, INC. (CA) | 2008-06-05 | — | — | US | disclosed |
| US-20070254185-A1 | Organic EL display device and organic thin film device | HITACHI DISPLAYS, LTD. (JP) | 2007-11-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130158034-A1 | TRPM8 ANTAGONISTS AND THEIR USE IN TREATMENTS | TRPM8, TRPM7, TRPM5 | PTGS2 711/4885HTR2A 411/4885HTR2C 593/4885 |
| US-20080132459-A1 | Inhibitors of Histone Deacetylase | HDAC1, HDAC5, HDAC3 | PTGS2 2854/4885HTR2A 4048/4885HTR2C 4325/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.