Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 5/20 | 0.57 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.47 |
| ▸ | CDK9 | P50750 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | STAT1 | P42224 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | GLA | P06280 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5564496 | 0.77 | MEN1 (0.42) | PDE4DMAPTCCNT1CDK9ALDH1A1 | |
| SCHEMBL31560182 | 0.77 | CDK9 (0.76) | CCNT1CDK9CSNK2A1 | |
| SCHEMBL31560185 | 0.76 | CDK9 (0.74) | CCNT1CDK9RAB9ANPC1CSNK2A1 | |
| SCHEMBL5564752 | 0.74 | EIF2AK2 (0.52) | CSNK2A1MEN1KMT2AATM | |
| SCHEMBL31560180 | 0.74 | KDM4E (0.54) | PDE4DMAPTALDH1A1RAB9ANPC1 | |
| SCHEMBL5564416 | 0.74 | MAPT (0.61) | PDE4DMAPTALDH1A1RAB9ANPC1 | |
| SCHEMBL31091478 | 0.74 | MAPT (0.61) | PDE4DMAPTALDH1A1RAB9ANPC1 | |
| SCHEMBL31560183 | 0.74 | ALDH1A1 (0.49) | PDE4DMAPTALDH1A1RAB9ANPC1 | |
| SCHEMBL5563977 | 0.73 | MAPK10 (0.45) | ALDH1A1KDM4EL3MBTL1PIM1MEN1 | |
| SCHEMBL1034547 | 0.73 | EIF2AK2 (0.58) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1504004-B1 | SUBSTITUTED PYRAZOLOPYRIMIDINES | SMITHKLINE BEECHAM CORP (US) | 2007-06-27 | — | — | EP | disclosed |
| US-20050203106-A1 | Therapeutic compounds | SMITHKLINE BEECHAM CORPORATION | 2005-09-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050203106-A1 | Therapeutic compounds | ABCB1, PCSK9, ABCB11 | PDE4D 723/4885MAPT 696/4885CCNT1 1011/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.