Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.54 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.46 |
| ▸ | METAP1 | P53582 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 5/20 | 0.42 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | NOS1 | P29475 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | FBP1 | P09467 | 1/20 | 0.39 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16112970 | 0.80 | PDPK1 (0.45) | PDPK1CYP2A6ADORA2AMETAP1RAB9A | |
| SCHEMBL102331 | 0.80 | PDPK1 (0.59) | PDPK1CYP2A6ADORA2AMETAP1RAB9A | |
| SCHEMBL22130295 | 0.80 | PDPK1 (0.67) | PDPK1CYP2A6METAP1RAB9ALOXL2 | |
| SCHEMBL17701190 | 0.78 | PDPK1 (0.43) | PDPK1CYP2A6ADORA2AMETAP1RAB9A | |
| SCHEMBL30534095 | 0.77 | PDPK1 (0.56) | PDPK1CYP2A6ADORA2AMETAP1RAB9A | |
| SCHEMBL30632310 | 0.77 | PDPK1 (0.56) | PDPK1CYP2A6ADORA2AMETAP1RAB9A | |
| SCHEMBL31556353 | 0.77 | PDPK1 (0.56) | PDPK1CYP2A6ADORA2AMETAP1RAB9A | |
| SCHEMBL28154527 | 0.77 | PDPK1 (0.56) | PDPK1CYP2A6ADORA2AMETAP1RAB9A | |
| SCHEMBL26658124 | 0.77 | RAB9A (0.42) | PDPK1CYP2A6ADORA2AMETAP1RAB9A | |
| SCHEMBL26635219 | 0.77 | ADORA2A (0.49) | PDPK1CYP2A6ADORA2ARAB9ALOXL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113149980-A | Tert-butyloxycarbonyl micromolecule organic compound targeting PUF60, derivative thereof and application thereof | 上海市奉贤区中心医院 | 2021-07-23 | — | — | CN | claimed |
| CN-101553232-A | Kinase inhibitors useful for the treatment of proliferative diseases | DECIPHERA PHARMACEUTICALS LLC (US) | 2009-10-07 | — | — | CN | claimed |
| CN-101553233-A | Kinase inhibitors useful for the treatment of myleoproliferative diseases and other proliferative diseases | DECIPHERA PHARMACEUTICALS LLC (US) | 2009-10-07 | — | — | CN | claimed |
| CN-101516379-A | Kinase inhibitors useful for the treatment of proliferative diseases | DECIPHERA PHARMACEUTICALS LLC (US) | 2009-08-26 | — | — | CN | claimed |
| US-12435076-B2 | Fluorine-containing pyrimidine compound and method for producing same | UNIMATEC CO., LTD. (JP) | 2025-10-07 | — | — | US | disclosed |
| US-20240124436-A1 | FLUORINE-CONTAINING PYRIMIDINE COMPOUND AND METHOD FOR PRODUCING SAME | UNIMATEC CO., LTD. (JP) | 2024-04-18 | — | — | US | disclosed |
| CN-114502551-B | Fluorine-containing pyrimidine compound and preparation method thereof | 优迈特株式会社 | 2023-08-22 | — | — | CN | disclosed |
| EP-4053123-A1 | FLUORINATED PYRIMIDINE COMPOUND AND METHOD FOR MANUFACTURING SAME | Unimatec Co., Ltd. (JP) | 2022-09-07 | — | — | EP | disclosed |
| CN-114502551-A | Fluorine-containing pyrimidine compound and preparation method thereof | 优迈特株式会社 | 2022-05-13 | — | — | CN | disclosed |
| CN-113149980-A | Tert-butyloxycarbonyl micromolecule organic compound targeting PUF60, derivative thereof and application thereof | 上海市奉贤区中心医院 | 2021-07-23 | — | — | CN | disclosed |
| WO-2021085550-A1 | FLUORINATED PYRIMIDINE COMPOUND AND METHOD FOR MANUFACTURING SAME | ユニマテック株式会社 | 2021-05-06 | — | — | WO | disclosed |
| CN-108040481-B | Pesticidally active polycyclic derivatives with sulfur-substituted five-membered ring heterocycles | 先正达参股股份有限公司 | 2020-10-30 | — | — | CN | disclosed |
| WO-2007124221-A1 | METHODS OF TREATING CELL PROLIFERATIVE DISORDERS BY USING PYRIMIDINEDIAMINE COMPOUNDS | RIGEL PHARMACEUTICALS, INC. (US) | 2007-11-01 | — | — | WO | disclosed |
| CN-1914199-A | Pyridyl or pyrimidyl thiazole compounds having protein kinase inhibitory activity | CYCLACEL LTD (GB) | 2007-02-14 | — | — | CN | disclosed |
| CN-1914199-A | Pyridyl or pyrimidyl thiazole compounds having protein kinase inhibitory activity | CYCLACEL LTD (GB) | 2007-02-14 | — | — | CN | disclosed |
| US-7105517-B2 | Thiazolyl substituted aminopyrimidines as plant protection agents | SYNGENTA CROP PROTECTION, INC. (US) | 2006-09-12 | — | — | US | disclosed |
| EP-1434776-B1 | THIAZOLYL SUBSTITUTED AMINOPYRIMIDINES AS PLANT PROTECTION AGENTS | SYNGENTA PARTICIPATIONS AG (CH) | 2006-06-28 | — | — | EP | disclosed |
| US-20050038059-A1 | Thiazolyl substituted aminopyrimidines as plant protection agents | SYNGENTA CROP PROTECTION, INC. | 2005-02-17 | — | — | US | disclosed |
| EP-1434776-A1 | THIAZOLYL SUBSTITUTED AMINOPYRIMIDINES AS PLANT PROTECTION AGENTS | Syngenta Participations AG (CH) | 2004-07-07 | — | — | EP | disclosed |
| WO-2003029249-A1 | THIAZOLYL SUBSTITUTED AMINOPYRIMIDINES AS PLANT PROTECTION AGENTS | SYNGENTA PARTICIPATIONS AG (CH) | 2003-04-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050038059-A1 | Thiazolyl substituted aminopyrimidines as plant protection agents | RARS2, CYP4X1, QDPR | PDPK1 2278/4885CYP2A6 904/4885ADORA2A 1493/4885 |
| US-12435076-B2 | Fluorine-containing pyrimidine compound and method for producing same | CNOT1, HAO1, NUDT1 | PDPK1 2996/4885CYP2A6 512/4885ADORA2A 538/4885 |
| US-20240124436-A1 | FLUORINE-CONTAINING PYRIMIDINE COMPOUND AND METHOD FOR PRODUCING SAME | CNOT1, NUDT1, HAO1 | PDPK1 2962/4885CYP2A6 517/4885ADORA2A 542/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.