Sugi Predict

Sugi Predict / Compounds / SCHEMBL55705

SCHEMBL55705

SCHEMBL55705

[O]COc1ccccc1[O]

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 3/20 0.37
▸ SMN1; SMN2 Q16637 2/20 0.37
▸ HPGD P15428 1/20 0.37
▸ HTT P42858 1/20 0.37
▸ L3MBTL1 Q9Y468 3/20 0.36
▸ MAPT P10636 2/20 0.36
▸ NPSR1 Q6W5P4 1/20 0.36
▸ GLA P06280 1/20 0.36
▸ KDM4E B2RXH2 1/20 0.34
▸ GAA P10253 3/20 0.33
▸ NPC1 O15118 1/20 0.33
▸ RECQL P46063 1/20 0.33
▸ RAB9A P51151 1/20 0.33
▸ JAK2 O60674 1/20 0.33
▸ LMNA P02545 1/20 0.33
▸ HCRTR1 O43613 1/20 0.32
▸ POLB P06746 1/20 0.32
▸ CA12 O43570 1/20 0.32
▸ CA1 P00915 1/20 0.32
▸ CA2 P00918 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7055886 0.81 ALDH1A1 (0.43) ALDH1A1SMN1; SMN2HPGDHTTL3MBTL1
SCHEMBL482954 0.80 ALDH1A1 (0.58) ALDH1A1L3MBTL1MAPTNPSR1GLA
SCHEMBL6003548 0.78 DRD1 (0.46) ALDH1A1SMN1; SMN2HPGDHTTL3MBTL1
SCHEMBL7904254 0.78 ALDH1A1 (0.35) ALDH1A1SMN1; SMN2HPGDHTTL3MBTL1
SCHEMBL3015617 0.78 ALDH1A1 (0.35) ALDH1A1SMN1; SMN2HPGDHTTL3MBTL1
SCHEMBL7049447 0.78 ALDH1A1 (0.35) ALDH1A1SMN1; SMN2HPGDHTTL3MBTL1
SCHEMBL8764972 0.78 KDM4E (0.43) ALDH1A1SMN1; SMN2HPGDHTTL3MBTL1
SCHEMBL11481226 0.76 — —
SCHEMBL2090885 0.75 ALDH1A1 (0.53) ALDH1A1SMN1; SMN2HPGDMAPTNPSR1
SCHEMBL11607317 0.75 ALDH1A1 (0.42) ALDH1A1SMN1; SMN2HPGDHTTL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 155 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5654296-A HORMONE INHIBITOR; NERVOUS SYSTEM DISORDERS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1997-08-05 — — US claimed
US-5607939-A CALCIUM ANTAGONIST, GONADOTROPIN RELEASING HORMONE RECEPTOR ANTAGONIST AND MONOAMINEU UPTAKE INHIBITORS FOR CENTRAL NERVOUS SYSTEM DISORDERS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1997-03-04 — — US claimed
EP-0679642-A1 Condensed heterocyclic compounds, their production and use TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1995-11-02 — — EP claimed
US-4595769-A Carbamate-sulfenyl-carbamoyl fluoride compounds UNION CARBIDE CORPORATION (US) 1986-06-17 — — US claimed
US-4201780-A Mono-5-substituted-3-chloro-4H-1,2,6-thiadiazin-4-one antifungal agents FMC CORPORATION (US) 1980-05-06 — — US claimed
CN-108314663-B Derivatives of fluorene, anthracene, xanthene, dibenzosuberone and acridine and uses thereof 多格伍德药品公司 2022-05-13 — — CN disclosed
CN-108697714-B Fused pyrimidine compound or salt thereof 大鹏药品工业株式会社 2022-04-26 — — CN disclosed
US-11046696-B2 Fused pyrimidine compound or salt thereof TAIHO PHARMACEUTICAL CO., LTD. (JP) 2021-06-29 — — US disclosed
US-11008324-B2 — — 2021-05-18 — — US disclosed
US-10807986-B2 Fused pyrimidine compound or salt thereof TAIHO PHARMACEUTICAL CO., LTD. (JP) 2020-10-20 — — US disclosed
US-20200270253-A1 NOVEL FUSED PYRIMIDINE COMPOUND OR SALT THEREOF TAIHO PHARMACEUTICAL CO., LTD. (JP) 2020-08-27 — — US disclosed
US-20190330214-A1 NOVEL FUSED PYRIMIDINE COMPOUND OR SALT THEREOF TAIHO PHARMACEUTICAL CO., LTD. (JP) 2019-10-31 — — US disclosed
US-5654296-A HORMONE INHIBITOR; NERVOUS SYSTEM DISORDERS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1997-08-05 — — US disclosed
WO-1997025321-A2 SUBSTITUTED PHENYL COMPOUNDS AND DERIVATIVES THEREOF THAT MODULATE THE ACTIVITY OF ENDOTHELIN TEXAS BIOTECHNOLOGY CORPORATION (US) 1997-07-17 — — WO disclosed
US-5607939-A CALCIUM ANTAGONIST, GONADOTROPIN RELEASING HORMONE RECEPTOR ANTAGONIST AND MONOAMINEU UPTAKE INHIBITORS FOR CENTRAL NERVOUS SYSTEM DISORDERS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1997-03-04 — — US disclosed
EP-0679642-A1 Condensed heterocyclic compounds, their production and use TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1995-11-02 — — EP disclosed
EP-0329013-A2 Renin-inhibiting amino acid derivatives HOECHST AKTIENGESELLSCHAFT (DE) 1989-08-23 — — EP disclosed
US-4595769-A Carbamate-sulfenyl-carbamoyl fluoride compounds UNION CARBIDE CORPORATION (US) 1986-06-17 — — US disclosed
US-4338450-A Carbamate-sulfenyl-carbamoyl fluoride compounds UNION CARBIDE CORPORATION (US) 1982-07-06 — — US disclosed
US-4201780-A Mono-5-substituted-3-chloro-4H-1,2,6-thiadiazin-4-one antifungal agents FMC CORPORATION (US) 1980-05-06 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190330214-A1 NOVEL FUSED PYRIMIDINE COMPOUND OR SALT THEREOF RET, ZFX, PDCD11 ALDH1A1 1436/4885SMN1; SMN2 1023/4885HPGD 4066/4885
US-11046696-B2 Fused pyrimidine compound or salt thereof RET, ZFX, MECP2 ALDH1A1 1337/4885SMN1; SMN2 994/4885HPGD 3773/4885
US-11008324-B2 — RET, GFRA1, GFRA2 ALDH1A1 1265/4885SMN1; SMN2 1556/4885HPGD 4243/4885
US-10807986-B2 Fused pyrimidine compound or salt thereof RET, ZFX, MECP2 ALDH1A1 1337/4885SMN1; SMN2 994/4885HPGD 3773/4885
US-20200270253-A1 NOVEL FUSED PYRIMIDINE COMPOUND OR SALT THEREOF RET, ZFX, PDCD11 ALDH1A1 1436/4885SMN1; SMN2 1023/4885HPGD 4066/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.