Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | MDM2 | Q00987 | 4/20 | 0.37 |
| ▸ | KIF11 | P52732 | 1/20 | 0.36 |
| ▸ | CCR3 | P51677 | 2/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4913985 | 0.74 | MDM2 (0.61) | MDM2 | |
| SCHEMBL4913982 | 0.74 | MDM2 (0.61) | MDM2 | |
| SCHEMBL12083976 | 0.69 | MDM2 (0.54) | MDM2ALDH1A1 | |
| SCHEMBL5569403 | 0.68 | OPRM1 (0.50) | OPRM1SIGMAR1MEN1ALDH1A1KMT2A | |
| SCHEMBL5573072 | 0.67 | OPRM1 (0.51) | OPRM1MDM2SIGMAR1 | |
| SCHEMBL4912405 | 0.66 | MDM2 (0.62) | MDM2ALDH1A1 | |
| SCHEMBL4912401 | 0.66 | MDM2 (0.62) | MDM2ALDH1A1 | |
| SCHEMBL5573856 | 0.63 | HTT (0.41) | OPRM1MDM2SIGMAR1 | |
| SCHEMBL9037683 | 0.62 | SIGMAR1 (0.49) | OPRM1SIGMAR1 | |
| SCHEMBL5247617 | 0.62 | SLC6A2 (0.40) | OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1786773-A1 | ISOINDOLIN-1-ONE DERIVATIVES | Cancer Research Technology Limited (GB) | 2007-05-23 | — | — | EP | disclosed |
| WO-2006024837-A1 | ISOINDOLIN-1-ONE DERIVATIVES | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2006-03-09 | — | — | WO | disclosed |