Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 8/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5569403 | 0.81 | OPRM1 (0.50) | SIGMAR1CYP1A2CYP2D6CYP2C19MEN1 | |
| SCHEMBL5570570 | 0.71 | TP53 (0.58) | SIGMAR1TP53CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL2792683 | 0.71 | SIGMAR1 (0.51) | SIGMAR1TP53CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL5138623 | 0.69 | AMPD2 (0.41) | SIGMAR1TP53CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL27685059 | 0.68 | NPC1 (0.36) | SIGMAR1TP53ALDH1A1 | |
| SCHEMBL27345750 | 0.68 | SIGMAR1 (0.48) | SIGMAR1TP53CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL9374898 | 0.68 | SIGMAR1 (0.48) | SIGMAR1TP53CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL9374100 | 0.67 | SIGMAR1 (0.50) | SIGMAR1TP53CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL28824723 | 0.66 | SIGMAR1 (0.45) | SIGMAR1CYP3A4TSHRMEN1KMT2A | |
| SCHEMBL9375293 | 0.66 | SIGMAR1 (0.46) | SIGMAR1TP53CYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1786773-A1 | ISOINDOLIN-1-ONE DERIVATIVES | Cancer Research Technology Limited (GB) | 2007-05-23 | — | — | EP | disclosed |
| WO-2006024837-A1 | ISOINDOLIN-1-ONE DERIVATIVES | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2006-03-09 | — | — | WO | disclosed |