Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STS | P08842 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5573655 | 0.80 | STS (0.30) | STS | |
| Hydrochloric Acid SCHEMBL2064723 | 0.76 | POLB (0.37) | KDM4ESMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL175377 | 0.76 | POLB (0.37) | KDM4ESMN1; SMN2 | |
| SCHEMBL1500496 | 0.76 | LMNA (0.45) | KDM4ESMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL4119676 | 0.74 | POLB (0.38) | KDM4ESMN1; SMN2 | |
| Iodide SCHEMBL2464728 | 0.73 | POLB (0.37) | KDM4ESMN1; SMN2 | |
| Bromide SCHEMBL2467102 | 0.73 | POLB (0.37) | KDM4ESMN1; SMN2 | |
| SCHEMBL1451334 | 0.70 | ALDH1A1 (0.44) | KDM4ESMN1; SMN2 | |
| Pyridine SCHEMBL6100271 | 0.70 | SMN1; SMN2 (0.33) | KDM4ESMN1; SMN2 | |
| SCHEMBL9326235 | 0.65 | LMNA (0.59) | KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7252883-B2 | Coated particles | SEKISUI CHEMICAL CO., LTD. (JP) | 2007-08-07 | — | — | US | disclosed |
| US-20040109995-A1 | Coated particles | SEKISUI CHEMICAL CO., LTD. (JP) | 2004-06-10 | — | — | US | disclosed |
| EP-1335389-A1 | COATED PARTICLE | SEKISUI CHEMICAL CO., LTD. (JP) | 2003-08-13 | — | — | EP | disclosed |