Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL5574975 | 1.00 | ACHE (0.62) | ACHENPY2R | |
| Zanapezil SCHEMBL1232174 | 0.82 | ACHE (0.91) | ACHE | |
| Zanapezil SCHEMBL1232176 | 0.82 | ACHE (0.91) | ACHE | |
| Fumaric Acid SCHEMBL9203761 | 0.81 | ACHE (0.91) | ACHE | |
| Fumaric Acid SCHEMBL9203739 | 0.81 | ACHE (0.91) | ACHE | |
| SCHEMBL5638535 | 0.80 | ACHE (0.71) | ACHE | |
| SCHEMBL6768828 | 0.80 | ACHE (0.70) | ACHE | |
| Fumaric Acid SCHEMBL9200378 | 0.79 | ACHE (0.91) | ACHE | |
| Fumaric Acid SCHEMBL9200365 | 0.79 | ACHE (0.91) | ACHE | |
| Fumaric Acid SCHEMBL23668767 | 0.78 | ACHE (0.67) | ACHENPY2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5962535-A | SYNERGISTIC MIXTURE OF IDEBENONE AND ACETYLCHOLINESTERASE INHIBITOR | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1999-10-05 | — | — | US | claimed |
| US-7266457-B1 | High throughput functional genomics | HESPEROS, LLC (US) | 2007-09-04 | — | — | US | disclosed |
| US-5962535-A | SYNERGISTIC MIXTURE OF IDEBENONE AND ACETYLCHOLINESTERASE INHIBITOR | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1999-10-05 | — | — | US | disclosed |