Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.31 |
| ▸ | APEX1 | P27695 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5576290 | 0.90 | ELANE (0.46) | ELANEKMT2AATMMAPTPOLB | |
| SCHEMBL9619081 | 0.89 | MAPT (0.37) | ELANEKMT2AMAPTPOLBPKM | |
| SCHEMBL246655 | 0.89 | ELANE (0.56) | ELANEKMT2AATMMAPTPOLB | |
| SCHEMBL30313539 | 0.87 | ELANE (0.48) | ELANEKMT2AATMMAPTPOLB | |
| Trifluoromethanesulfonic Acid SCHEMBL31564995 | 0.82 | ELANE (0.43) | ELANEKMT2AATMMAPTPOLB | |
| SCHEMBL9487566 | 0.81 | THRB (0.45) | ELANEKMT2AMAPTPOLBPKM | |
| SCHEMBL9442120 | 0.80 | PKM (0.39) | ELANEKMT2AMAPTPOLBPKM | |
| SCHEMBL9619082 | 0.78 | MAPT (0.40) | ELANEKMT2AMAPTPOLBPKM | |
| Methylsulfanylmethane SCHEMBL27676791 | 0.78 | ELANE (0.55) | ELANEKMT2AATMMAPTPOLB | |
| SCHEMBL56436 | 0.77 | ELANE (0.69) | ELANEKMT2AATMMAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-5070720-A | — | — | None | — | — | JP | disclosed |
| JP-6228086-A | — | — | None | — | — | JP | disclosed |
| US-7252883-B2 | Coated particles | SEKISUI CHEMICAL CO., LTD. (JP) | 2007-08-07 | — | — | US | disclosed |
| US-20040109995-A1 | Coated particles | SEKISUI CHEMICAL CO., LTD. (JP) | 2004-06-10 | — | — | US | disclosed |
| JP-H06228086-A | MONOMER AND ITS POLYMER | SANSHIN CHEM IND CO LTD | 1994-08-16 | — | — | JP | disclosed |
| JP-H0570720-A | ADDITIVE FOR COATING MATERIAL | SANSHIN CHEM IND CO LTD | 1993-03-23 | — | — | JP | disclosed |