Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | TGM2 | P21980 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | THRA | P10827 | 1/20 | 0.31 |
| ▸ | PDE6D | O43924 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | TTR | P02766 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9487568 | 0.90 | THRB (0.44) | THRBMAPTPOLBPKMTGM2 | |
| SCHEMBL246091 | 0.89 | THRB (0.54) | THRBMAPTPOLBPKMTGM2 | |
| SCHEMBL9619081 | 0.84 | MAPT (0.37) | MAPTPOLBPKMELANELMNA | |
| SCHEMBL9442120 | 0.81 | PKM (0.39) | MAPTPOLBPKMELANELMNA | |
| Trifluoromethanesulfonic Acid SCHEMBL30925711 | 0.81 | THRB (0.42) | THRBMAPTPOLBPKMELANE | |
| SCHEMBL9351931 | 0.81 | CYP3A4 (0.34) | THRBMAPTPOLBPKMKMT2A | |
| SCHEMBL5576286 | 0.81 | ELANE (0.47) | MAPTPOLBPKMELANELMNA | |
| SCHEMBL9356342 | 0.77 | ELANE (0.53) | MAPTPOLBPKMELANEKMT2A | |
| SCHEMBL2587522 | 0.74 | THRB (0.64) | THRBMAPTPKMTGM2ELANE | |
| SCHEMBL9356273 | 0.73 | ELANE (0.42) | MAPTELANELMNAKMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-5032618-A | — | — | None | — | — | JP | disclosed |
| JP-5043714-A | — | — | None | — | — | JP | disclosed |
| JP-H0543714-A | FILM | SANSHIN CHEM IND CO LTD | 1993-02-23 | — | — | JP | disclosed |
| JP-H0532618-A | NEW ACRYLATE COMPOUND | SANSHIN CHEM IND CO LTD | 1993-02-09 | — | — | JP | disclosed |