Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 2/20 | 0.65 |
| ▸ | CISD1 | Q9NZ45 | 2/20 | 0.65 |
| ▸ | MAOB | P27338 | 1/20 | 0.61 |
| ▸ | CA2 | P00918 | 1/20 | 0.60 |
| ▸ | PPARG | P37231 | 5/20 | 0.55 |
| ▸ | MPC2 | O95563 | 1/20 | 0.55 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | FFAR1 | O14842 | 4/20 | 0.51 |
| ▸ | THRA | P10827 | 2/20 | 0.50 |
| ▸ | THRB | P10828 | 2/20 | 0.50 |
| ▸ | PPARA | Q07869 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1247602 | 0.85 | PPARG (0.66) | MAOACISD1MAOBCA2PPARG | |
| SCHEMBL11161463 | 0.85 | MAOA (0.61) | MAOACISD1MAOBCA2PPARG | |
| SCHEMBL3840336 | 0.84 | FFAR1 (0.65) | MAOACISD1CA2PPARGMPC2 | |
| SCHEMBL11168133 | 0.82 | PTPN1 (0.65) | MAOACISD1MAOBCA2PPARG | |
| SCHEMBL13846731 | 0.81 | CA2 (0.64) | MAOACISD1MAOBCA2PPARG | |
| SCHEMBL8172479 | 0.81 | MAOA (0.65) | MAOACISD1MAOBCA2PPARG | |
| SCHEMBL6930322 | 0.80 | PPARG (0.82) | CA2PPARGMPC2CYP2C8CYP2C9 | |
| SCHEMBL6373150 | 0.79 | ALDH1A1 (0.57) | MAOACISD1MAOBCA2PPARG | |
| SCHEMBL13347287 | 0.79 | PPARG (0.69) | MAOACISD1CA2PPARGMPC2 | |
| SCHEMBL5052419 | 0.79 | PPARG (0.69) | MAOACISD1CA2PPARGMPC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4376777-A | Thiazolidine derivatives use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1983-03-15 | — | — | US | claimed |
| US-7202366-B2 | Heterocyclic analogs of diphenylethylene compounds | THERACOS, INC. (US) | 2007-04-10 | — | — | US | disclosed |
| US-7202366-B2 | Heterocyclic analogs of diphenylethylene compounds | THERACOS, INC. (US) | 2007-04-10 | — | — | US | disclosed |
| US-7202366-B2 | Heterocyclic analogs of diphenylethylene compounds | THERACOS, INC. (US) | 2007-04-10 | — | — | US | disclosed |
| US-7105552-B2 | Heterocyclic analogs of diphenylethylene compounds | THERACOS, INC. (US) | 2006-09-12 | — | — | US | disclosed |
| US-20040186299-A1 | Novel heterocyclic analogs of diphenylethylene compounds | THERACOS, INC. | 2004-09-23 | — | — | US | disclosed |
| EP-1360178-A2 | NOVEL HETEROCYCLIC ANALOGS OF DIPHENYLETHYLENE COMPOUNDS | Calyx Therapeutics, Inc. (US) | 2003-11-12 | — | — | EP | disclosed |
| US-20020032225-A1 | Novel heterocyclic analogs of diphenylethylene compounds | SEED, BRIAN | 2002-03-14 | — | — | US | disclosed |
| WO-2001095859-A2 | NOVEL HETEROCYCLIC ANALOGS OF DIPHENYLETHYLENE COMPOUNDS | CALYX THERAPEUTICS, INC. (US) | 2001-12-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040186299-A1 | Novel heterocyclic analogs of diphenylethylene compounds | FFAR2, GPR119, FFAR4 | MAOA 3749/4885CISD1 2383/4885MAOB 2602/4885 |
| US-20020032225-A1 | Novel heterocyclic analogs of diphenylethylene compounds | FFAR2, GPR119, FFAR4 | MAOA 3749/4885CISD1 2383/4885MAOB 2602/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.