Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 2/20 | 0.32 |
| ▸ | THRB | P10828 | 2/20 | 0.32 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.32 |
| ▸ | AKT1 | P31749 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4930903 | 0.83 | KCNH2 (0.40) | — | |
| SCHEMBL4933433 | 0.77 | THRA (0.44) | THRATHRB | |
| SCHEMBL5577199 | 0.71 | TSHR (0.33) | — | |
| SCHEMBL4925823 | 0.62 | GPR119 (0.40) | — | |
| SCHEMBL27250643 | 0.61 | HTR1A (0.36) | — | |
| SCHEMBL16432438 | 0.60 | IGF1R (0.43) | THRB | |
| SCHEMBL29182741 | 0.60 | HTR1A (0.31) | — | |
| SCHEMBL18210667 | 0.60 | MAPT (0.46) | — | |
| SCHEMBL16430166 | 0.60 | ALDH1A1 (0.42) | — | |
| SCHEMBL21122530 | 0.59 | MAPK1 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1750727-A2 | KINASE MODULATORS AND METHODS OF USE | Exelixis, Inc. (US) | 2007-02-14 | — | — | EP | disclosed |
| WO-2005117909-A2 | KINASE MODULATORS AND METHODS OF USE | EXELIXIS, INC. (US) | 2005-12-15 | — | — | WO | disclosed |