Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4928045 | 0.81 | MEN1 (0.44) | LMNA | |
| SCHEMBL4934516 | 0.73 | PSIP1 (0.43) | TSHRLMNA | |
| SCHEMBL5577202 | 0.71 | THRA (0.32) | — | |
| SCHEMBL29130968 | 0.66 | BRD4 (0.42) | TSHRMAPK1LMNA | |
| SCHEMBL16432438 | 0.62 | IGF1R (0.43) | TSHRMAPK1LMNA | |
| SCHEMBL5577210 | 0.61 | NPSR1 (0.34) | TSHRLMNA | |
| SCHEMBL25247566 | 0.61 | PSIP1 (0.41) | TSHRLMNA | |
| SCHEMBL10696321 | 0.61 | CA2 (0.61) | TSHRLMNA | |
| SCHEMBL28105826 | 0.60 | PDPK1 (0.32) | TSHRLMNA | |
| SCHEMBL5577214 | 0.60 | ALDH1A1 (0.34) | TSHRMAPK1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1750727-A2 | KINASE MODULATORS AND METHODS OF USE | Exelixis, Inc. (US) | 2007-02-14 | — | — | EP | disclosed |
| WO-2005117909-A2 | KINASE MODULATORS AND METHODS OF USE | EXELIXIS, INC. (US) | 2005-12-15 | — | — | WO | disclosed |