Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.65 |
| ▸ | RAD52 | P43351 | 3/20 | 0.65 |
| ▸ | TOP2A | P11388 | 4/20 | 0.61 |
| ▸ | RAB9A | P51151 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | MITF | O75030 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | TTR | P02766 | 1/20 | 0.59 |
| ▸ | GLA | P06280 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.56 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.56 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15867118 | 0.98 | POLB (0.67) | POLBRAD52TOP2ARAB9AALDH1A1 | |
| SCHEMBL3360006 | 0.87 | POLB (0.67) | POLBRAD52TOP2ARAB9AALDH1A1 | |
| SCHEMBL13856923 | 0.87 | POLB (0.77) | POLBRAD52RAB9AALDH1A1KDM4E | |
| SCHEMBL6033155 | 0.87 | POLB (0.77) | POLBRAD52RAB9AALDH1A1KDM4E | |
| SCHEMBL5578493 | 0.85 | POLB (0.79) | POLBRAD52RAB9AALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL18334834 | 0.84 | POLB (0.72) | POLBRAD52RAB9AALDH1A1KDM4E | |
| SCHEMBL15867121 | 0.84 | POLB (0.63) | POLBRAD52TOP2ARAB9AALDH1A1 | |
| SCHEMBL27513252 | 0.83 | TOP2A (0.54) | POLBRAD52TOP2ARAB9AALDH1A1 | |
| SCHEMBL15867120 | 0.83 | POLB (0.87) | POLBRAD52RAB9AALDH1A1KDM4E | |
| SCHEMBL28307696 | 0.82 | BCHE (0.81) | SLC2A1BCHEACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9090640-B2 | Targeted delivery and prodrug designs for platinum-acridine anti-cancer compounds and methods thereof | WAKE FOREST UNIVERSITY | 2015-07-28 | — | — | US | disclosed |
| US-20140193334-A1 | Targeted Delivery and Prodrug Designs for Platinum-Acridine Anti-Cancer Compounds and Methods Thereof | WAKE FOREST UNIVERSITY | 2014-07-10 | — | — | US | disclosed |
| US-20120035320-A1 | POLYACRIDINE NUCLEIC ACID DELIVERY PEPTIDE COMPLEXES | UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) | 2012-02-09 | — | — | US | disclosed |
| US-20100009970-A1 | COMPOSITIONS AND METHODS FOR TREATMENT OF VIRAL DISEASES | COMBINATORX (SINGAPORE) PTE. LTD. (SG) | 2010-01-14 | — | — | US | disclosed |
| US-20080161324-A1 | Compositions and methods for treatment of viral diseases | EXCRX (SINGAPORE) PTE. LTD. (F.K.A. COMBINATORX (SINGAPORE) PTE LTD.) (SG) | 2008-07-03 | — | — | US | disclosed |
| WO-2008033466-A2 | COMPOSITIONS AND METHODS FOR TREATMENT OF VIRAL DISEASES | COMBINATORX (SINGAPORE) PRE. LTD. (SG) | 2008-03-20 | — | — | WO | disclosed |
| EP-0968309-B1 | METHOD FOR DETERMINING A NUCLEIC ACID | GEORGIA TECH RES INST (US) | 2004-10-13 | — | — | EP | disclosed |
| US-6225052-B1 | HYBRIDIZING NUCLEIC ACID TO SYNTHETIC HYBRIDIZATION PROBE WHICH HAS NON-NATURAL BACKBONE AND WHICH IS LABELED WITH ELECTRON DONOR AND/OR ELECTRON ACCEPTOR, THEN ACTIVATING AND DETECTING ELECTRON TRANSFER | ROCHE DIAGNOSTICS GMBH (DE) | 2001-05-01 | — | — | US | disclosed |
| US-6117973-A | PEPTIDE NUCLEIC ACID MONOMERS; FOR USE AS PROBES TO DETECT NUCLEIC ACIDS | GEORGIA TECH RESEARCH CORP. (US) | 2000-09-12 | — | — | US | disclosed |
| EP-0968309-A2 | METHOD FOR DETERMINING A NUCLEIC ACID | GEORGIA TECH RESEARCH CORPORATION (US) | 2000-01-05 | — | — | EP | disclosed |
| WO-1998037232-A2 | METHOD FOR DETERMINING A NUCLEIC ACID | GEORGIA TECH RESEARCH CORPORATION (US) | 1998-08-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120035320-A1 | POLYACRIDINE NUCLEIC ACID DELIVERY PEPTIDE COMPLEXES | NUP205, PABPC1, SARNP | POLB 102/4885RAD52 1538/4885TOP2A 769/4885 |
| US-20100009970-A1 | COMPOSITIONS AND METHODS FOR TREATMENT OF VIRAL DISEASES | HTR1A, HTR3B, HTR3A | POLB 469/4885RAD52 4644/4885TOP2A 1167/4885 |
| US-20080161324-A1 | Compositions and methods for treatment of viral diseases | HAVCR2, EIF2AK2, RNASE1 | POLB 249/4885RAD52 4762/4885TOP2A 1871/4885 |
| US-20140193334-A1 | Targeted Delivery and Prodrug Designs for Platinum-Acridine Anti-Cancer Compounds and Methods Thereof | ERBB3, EGFR, ESR1 | POLB 4366/4885RAD52 2529/4885TOP2A 226/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.