Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.44 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.44 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 5/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | RGS12 | O14924 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | APEX1 | P27695 | 1/20 | 0.35 |
| ▸ | THPO | P40225 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16887598 | 0.82 | SMN1; SMN2 (0.33) | SMN1; SMN2LMNAPOLBTDP1MAPT | |
| SCHEMBL11060822 | 0.80 | GABRA5 (0.42) | HSD17B10GABRA5GABRB2EGLN1KDM4E | |
| SCHEMBL16886276 | 0.77 | CYP1A2 (0.45) | SMN1; SMN2TDP1L3MBTL1TSHRCYP1A2 | |
| SCHEMBL6122066 | 0.76 | GABRA5 (0.39) | HSD17B10GABRA5GABRB2EGLN1KDM4E | |
| SCHEMBL4273108 | 0.71 | NOS3 (0.39) | — | |
| SCHEMBL8551633 | 0.71 | SMN1; SMN2 (0.35) | KDM4ESMN1; SMN2TDP1 | |
| SCHEMBL27827475 | 0.71 | HSD17B10 (0.36) | HSD17B10GABRA5GABRB2EGLN1KDM4E | |
| SCHEMBL27837903 | 0.68 | GABRA5 (0.37) | HSD17B10GABRA5GABRB2EGLN1KDM4E | |
| Orotic Acid SCHEMBL185887 | 0.67 | ALOX15 (0.50) | EGLN1KDM4ESMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL25088030 | 0.67 | PKM (0.39) | HSD17B10KDM4ESMN1; SMN2LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7294642-B2 | 1,3-Diamino-2-hydroxypropane pro-drug derivatives | ELAN PHARMACEUTICALS, INC. (US) | 2007-11-13 | — | — | US | claimed |