Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 5/20 | 0.54 |
| ▸ | MAPT | P10636 | 5/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.52 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.52 |
| ▸ | RELA | Q04206 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | POLB | P06746 | 3/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | GLA | P06280 | 1/20 | 0.52 |
| ▸ | APEX1 | P27695 | 1/20 | 0.52 |
| ▸ | CTSS | P25774 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19387376 | 0.69 | ALDH1A1 (0.76) | HPGDRAB9AMAPTSMN1; SMN2MEN1 | |
| SCHEMBL14096099 | 0.69 | HPGD (0.80) | HPGDMAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL18180599 | 0.69 | NPC1 (1.00) | HPGDRAB9AMAPTSMN1; SMN2MEN1 | |
| SCHEMBL10073059 | 0.67 | HPGD (0.64) | HPGDRAB9AMAPTSMN1; SMN2MEN1 | |
| SCHEMBL11687560 | 0.65 | MAPT (0.62) | HPGDRAB9AMAPTSMN1; SMN2MEN1 | |
| SCHEMBL1238797 | 0.64 | HPGD (0.44) | HPGDRAB9AMAPTSMN1; SMN2MEN1 | |
| SCHEMBL28275043 | 0.64 | ALDH1A1 (1.00) | HPGDRAB9AMAPTSMN1; SMN2MEN1 | |
| SCHEMBL4199720 | 0.64 | TAS1R3 (1.00) | HPGDRAB9AMAPTSMN1; SMN2MEN1 | |
| SCHEMBL28275041 | 0.64 | ALDH1A1 (1.00) | HPGDRAB9AMAPTSMN1; SMN2MEN1 | |
| SCHEMBL6084166 | 0.63 | RAB9A (0.78) | HPGDRAB9AMAPTSMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120035179-A1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | VERTEX PHARMACEUTICALS INCORPORATED | 2012-02-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120035179-A1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | ABCB11, ABCB1, ABCC5 | HPGD 1656/4885RAB9A 672/4885MAPT 2703/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.