Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | PIM1 | P11309 | 8/20 | 0.39 |
| ▸ | PIM2 | Q9P1W9 | 6/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.36 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | CES1 | P23141 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL210033 | 0.84 | HDAC1 (0.47) | TP53NPC1RAB9A | |
| SCHEMBL5583439 | 0.82 | LMNA (0.45) | LMNATP53PIM1PIM2 | |
| SCHEMBL5583397 | 0.76 | DHFR (0.53) | LMNATP53TAS1R3TAS1R1KMT2A | |
| SCHEMBL3558423 | 0.74 | TUBB4A (0.54) | LMNATP53NPC1KMT2AALDH1A1 | |
| SCHEMBL5583428 | 0.73 | HIF1A (0.58) | LMNATP53TAS1R3TAS1R1KMT2A | |
| SCHEMBL4592146 | 0.73 | CXCR4 (0.46) | LMNATP53NPC1RAB9ANAMPT | |
| SCHEMBL5583395 | 0.73 | PIM1 (0.59) | TP53PIM1PIM2NPC1RAB9A | |
| SCHEMBL3560484 | 0.72 | LMNA (0.56) | LMNATP53RAB9AKMT2AALDH1A1 | |
| SCHEMBL12047718 | 0.69 | ALDH1A1 (0.46) | NPC1RAB9ANAMPTKMT2AALDH1A1 | |
| SCHEMBL5583473 | 0.68 | LMNA (0.56) | LMNATP53PIM1ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070213330-A1 | Anticancer agents; antiproliferative agents | METHYLGENE INC. (CA) | 2007-09-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070213330-A1 | Anticancer agents; antiproliferative agents | HDAC1, HDAC11, HDAC5 | LMNA 1962/4885TP53 86/4885PIM1 2009/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.