Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | MMP2 | P08253 | 1/20 | 0.30 |
| ▸ | MMP3 | P08254 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27734469 | 0.82 | NPC1 (0.32) | ALDH1A1PKMNPC1RAB9ATSHR | |
| SCHEMBL27637698 | 0.81 | HDAC4 (0.31) | ALDH1A1NPC1RAB9ATSHRSMN1; SMN2 | |
| SCHEMBL8957775 | 0.75 | HDAC1 (0.37) | ALDH1A1HDAC1HDAC2NPC1RAB9A | |
| Methane SCHEMBL28875106 | 0.74 | HDAC1 (0.36) | ALDH1A1HDAC1HDAC2NPC1RAB9A | |
| SCHEMBL9006818 | 0.73 | THRB (0.35) | ALDH1A1HDAC1HDAC2NPC1RAB9A | |
| SCHEMBL28658397 | 0.73 | HDAC1 (0.33) | ALDH1A1HDAC1HDAC2NPC1RAB9A | |
| SCHEMBL28424483 | 0.73 | PTGS2 (0.32) | ALDH1A1NPC1RAB9ALMNA | |
| SCHEMBL5067245 | 0.73 | HDAC1 (0.35) | ALDH1A1HDAC1HDAC2NPC1RAB9A | |
| SCHEMBL5131865 | 0.73 | HDAC1 (0.35) | ALDH1A1HDAC1HDAC2NPC1RAB9A | |
| SCHEMBL9766554 | 0.72 | PTGS2 (0.37) | ALDH1A1HDAC2TSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007520453-A | — | — | 2007-07-26 | — | — | JP | claimed |
| EP-1682499-A1 | 4-BIARYLYL-1-PHENYLAZETIDIN-2-ONES | Microbia, Inc. (US) | 2006-07-26 | — | — | EP | claimed |
| WO-2005047248-A1 | 4-BIARYLYL-1-PHENYLAZETIDIN-2-ONES | MICROBIA, INC. (US) | 2005-05-26 | — | — | WO | claimed |