Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | HTR7 | P34969 | 1/20 | 0.48 |
| ▸ | TDO2 | P48775 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | PPARD | Q03181 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27705416 | 0.87 | HTR1A (0.50) | HTR1AHTR7TDO2PPARGPPARD | |
| SCHEMBL27723675 | 0.83 | KDM1A (0.41) | HTR1AHTR7TDO2PPARGPPARD | |
| SCHEMBL27703110 | 0.80 | NPSR1 (0.45) | HTR1AHTR7TDO2MEN1MAPT | |
| SCHEMBL5583652 | 0.80 | ENPP3 (0.40) | SMN1; SMN2GSK3BDYRK1ACLK4 | |
| SCHEMBL5586538 | 0.80 | CYP3A4 (0.49) | MEN1MAPTKMT2ASMN1; SMN2CYP1A1 | |
| SCHEMBL5586539 | 0.77 | HTR1A (0.44) | HTR1AHTR7MEN1MAPTKMT2A | |
| SCHEMBL4597055 | 0.74 | HTR1A (0.49) | HTR1AHTR7TDO2CD274NOTUM | |
| SCHEMBL4761887 | 0.73 | HTR1A (0.48) | HTR1AHTR7MAPTNOTUMALDH1A1 | |
| SCHEMBL4597054 | 0.73 | HTR1A (0.48) | HTR1AHTR7TDO2CD274NOTUM | |
| SCHEMBL2020140 | 0.73 | ABL1 (0.59) | TDO2SMN1; SMN2CYP1A1CYP1A2CYP2E1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007509174-A | — | — | 2007-04-12 | — | — | JP | claimed |
| EP-1675840-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | Wyeth a Corporation of the State of Delaware (US) | 2006-07-05 | — | — | EP | claimed |
| WO-2005044812-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | WYETH A CORPORATION OF THE STATE OF DELAWARE (US) | 2005-05-19 | — | — | WO | claimed |