Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.44 |
| ▸ | HTR7 | P34969 | 2/20 | 0.44 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.35 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
| ▸ | RELA | Q04206 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28769082 | 0.86 | HTR1A (0.37) | HTR1AHTR7NOTUMTAAR1ESR2 | |
| SCHEMBL5583652 | 0.81 | ENPP3 (0.40) | PARP10PARP11ALOX15ALOX12SMN1; SMN2 | |
| SCHEMBL5583557 | 0.81 | HTR1A (0.44) | HTR1AHTR7NOTUMTAAR1PARP10 | |
| SCHEMBL4761887 | 0.80 | HTR1A (0.48) | HTR1AHTR7NOTUMPARP10PARP11 | |
| SCHEMBL27703048 | 0.80 | HTR1A (0.36) | HTR1AHTR7TAAR1ESR2PARP10 | |
| SCHEMBL5583548 | 0.77 | HTR1A (0.48) | HTR1AHTR7NOTUMMAPTLMNA | |
| SCHEMBL5586507 | 0.75 | HTR1A (0.47) | HTR1AHTR7NOTUMPARP10PARP11 | |
| SCHEMBL5586519 | 0.73 | NPC1 (0.35) | HTR7MAPTLMNATP53ALOX15 | |
| SCHEMBL6374163 | 0.73 | BCAT1 (0.33) | HTR1AHTR7PIK3R1PIK3CAPDE3B | |
| SCHEMBL5583665 | 0.73 | CYP11B1 (0.47) | MAPTLMNATP53ALOX15SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007509174-A | — | — | 2007-04-12 | — | — | JP | claimed |
| EP-1675840-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | Wyeth a Corporation of the State of Delaware (US) | 2006-07-05 | — | — | EP | claimed |
| WO-2005044812-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | WYETH A CORPORATION OF THE STATE OF DELAWARE (US) | 2005-05-19 | — | — | WO | claimed |