SCHEMBL5583636

SCHEMBL5583636

Cc1c[c]ccc1Oc1ccc(C(F)(F)F)cc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC6A4 P31645 6/20 0.43
HTR2A P28223 4/20 0.43
KCNH2 Q12809 4/20 0.43
L3MBTL1 Q9Y468 2/20 0.41
RAB9A P51151 1/20 0.41
MAPT P10636 3/20 0.38
LMNA P02545 1/20 0.38
ATM Q13315 1/20 0.38
FFAR1 O14842 1/20 0.38
AR P10275 1/20 0.37
PPARD Q03181 3/20 0.35
KDM4E B2RXH2 1/20 0.35
MAPK1 P28482 1/20 0.34
SLC6A2 P23975 1/20 0.34
SLC6A3 Q01959 1/20 0.34
CA1 P00915 1/20 0.34
CA2 P00918 1/20 0.34
CA9 Q16790 1/20 0.34
DYRK3 O43781 1/20 0.34
MAP4K4 O95819 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2262445 0.85 RAB9A (0.44) RAB9AMAPTLMNAKDM4EMAPK1
SCHEMBL5583620 0.82 L3MBTL1 (0.39) SLC6A4HTR2AKCNH2L3MBTL1RAB9A
SCHEMBL5583617 0.82 TEAD1 (0.46) L3MBTL1MAPTLMNAATMAR
SCHEMBL2264473 0.81 CYP1A2 (0.38) SLC6A4HTR2AKCNH2L3MBTL1LMNA
SCHEMBL2268413 0.81 TEAD4 (0.41) SLC6A4HTR2AKCNH2MAPTLMNA
SCHEMBL21630261 0.81 FFAR1 (0.42) SLC6A4HTR2AKCNH2L3MBTL1RAB9A
SCHEMBL21630320 0.81 SLC6A4 (0.43) SLC6A4HTR2AKCNH2L3MBTL1RAB9A
SCHEMBL2265983 0.80 POLB (0.42) SLC6A4L3MBTL1RAB9ALMNAAR
SCHEMBL2263268 0.78 LTA4H (0.44) L3MBTL1ARMAPK1CA1CA2
SCHEMBL5583829 0.78 LTA4H (0.41) SLC6A4HTR2AL3MBTL1LMNAMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7183278-B1 Picolinamide derivative and harmful organism control agent comprising said picolinamide derivative as active component MEIJI SEIKA KAISHA, LTD. (JP) 2007-02-27 US claimed
EP-1134214-A1 PICOLINAMIDE DERIVATIVES AND PEST CONTROLLERS CONTAINING THE SAME AS THE ACTIVE INGREDIENT MEIJI SEIKA KAISHA LTD. (JP) 2001-09-19 EP claimed
US-7183278-B1 Picolinamide derivative and harmful organism control agent comprising said picolinamide derivative as active component MEIJI SEIKA KAISHA, LTD. (JP) 2007-02-27 US disclosed
EP-1134214-A1 PICOLINAMIDE DERIVATIVES AND PEST CONTROLLERS CONTAINING THE SAME AS THE ACTIVE INGREDIENT MEIJI SEIKA KAISHA LTD. (JP) 2001-09-19 EP disclosed