SCHEMBL5583620

SCHEMBL5583620

FC(F)(F)c1ccc(Oc2cc[c]cc2C(F)(F)F)cc1

nearest known ligand 0.44

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 2/20 0.39
RAB9A P51151 1/20 0.39
SLC6A4 P31645 6/20 0.38
HTR2A P28223 4/20 0.38
KCNH2 Q12809 4/20 0.38
LMNA P02545 2/20 0.37
KDM4E B2RXH2 2/20 0.37
MAPT P10636 2/20 0.36
ATM Q13315 1/20 0.36
ICAM1 P05362 2/20 0.35
SELE P16581 2/20 0.35
CA1 P00915 1/20 0.35
CA2 P00918 1/20 0.35
CA9 Q16790 1/20 0.35
LTA4H P09960 2/20 0.34
PTGS2 P35354 1/20 0.33
SLC6A2 P23975 1/20 0.33
SLC6A3 Q01959 1/20 0.33
KIF11 P52732 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5583758 0.85 AR (0.47) SLC6A4HTR2AKCNH2MAPT
SCHEMBL5583698 0.85 AR (0.37) RAB9ALMNAMAPTLTA4HPTGS2
SCHEMBL4215181 0.82 RXRA (0.39) L3MBTL1RAB9ASLC6A4HTR2AKCNH2
SCHEMBL21630320 0.82 SLC6A4 (0.43) L3MBTL1RAB9ASLC6A4HTR2AKCNH2
SCHEMBL21630261 0.82 FFAR1 (0.42) L3MBTL1RAB9ASLC6A4HTR2AKCNH2
SCHEMBL5583636 0.82 SLC6A4 (0.43) L3MBTL1RAB9ASLC6A4HTR2AKCNH2
SCHEMBL1692003 0.79 SLC6A4 (0.42) L3MBTL1RAB9ASLC6A4HTR2AKCNH2
SCHEMBL455068 0.76 LTA4H (0.44) L3MBTL1RAB9ASLC6A4HTR2AKCNH2
SCHEMBL14677727 0.75 LTA4H (0.52) L3MBTL1RAB9ASLC6A4LMNAKDM4E
SCHEMBL1069020 0.74 HSD11B1 (0.34)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7183278-B1 Picolinamide derivative and harmful organism control agent comprising said picolinamide derivative as active component MEIJI SEIKA KAISHA, LTD. (JP) 2007-02-27 US claimed
EP-1134214-A1 PICOLINAMIDE DERIVATIVES AND PEST CONTROLLERS CONTAINING THE SAME AS THE ACTIVE INGREDIENT MEIJI SEIKA KAISHA LTD. (JP) 2001-09-19 EP claimed
US-7183278-B1 Picolinamide derivative and harmful organism control agent comprising said picolinamide derivative as active component MEIJI SEIKA KAISHA, LTD. (JP) 2007-02-27 US disclosed
EP-1134214-A1 PICOLINAMIDE DERIVATIVES AND PEST CONTROLLERS CONTAINING THE SAME AS THE ACTIVE INGREDIENT MEIJI SEIKA KAISHA LTD. (JP) 2001-09-19 EP disclosed