Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SETDB1 | Q15047 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.40 |
| ▸ | CA9 | Q16790 | 2/20 | 0.40 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | HTR1D | P28221 | 1/20 | 0.39 |
| ▸ | HTR1B | P28222 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14075127 | 0.88 | SETDB1 (0.48) | SETDB1CYP3A4CYP2A6MAPTHPGD | |
| SCHEMBL3820470 | 0.82 | CYP3A4 (0.57) | SETDB1CYP3A4CYP2A6MAPTKDM4E | |
| SCHEMBL5826025 | 0.81 | SETDB1 (0.43) | SETDB1CYP3A4CYP2A6MAPTHPGD | |
| SCHEMBL94786 | 0.81 | KDM4E (0.48) | CYP3A4MAPTKDM4ENR3C1HTR1A | |
| SCHEMBL23412378 | 0.80 | MAPT (0.52) | MAPTKDM4EHPGDNR3C1HTR1A | |
| SCHEMBL10366733 | 0.80 | MAPT (0.44) | SETDB1CYP3A4MAPTKDM4EHPGD | |
| SCHEMBL23412188 | 0.79 | NCF1 (0.51) | MAPTKDM4EHPGDHTR1AHTR1D | |
| SCHEMBL96151 | 0.78 | HTR1A (0.45) | MAPTKDM4EHPGDNR3C1HTR1A | |
| SCHEMBL23412437 | 0.77 | NCF1 (0.58) | MAPTKDM4EHPGDHTR1AHTR1D | |
| SCHEMBL9601934 | 0.77 | SYK (0.54) | MAPTKDM4EMAPK1HSD17B10NR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9980954-B2 | Quinoline derivatives for inhibiting histone methyltransferases and use thereof | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2018-05-29 | — | — | US | disclosed |
| US-20170354650-A1 | QUINOLINE DERIVATIVES FOR INHIBITING HISTONE METHYLTRANSFERASES AND USE THEREOF | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2017-12-14 | — | — | US | disclosed |
| CN-100384849-C | Quinoline 3-Aminochroman Derivatives | WYETH CORP (US) | 2008-04-30 | — | — | CN | disclosed |
| US-20070191417-A1 | QUINOLINE 3-AMINO CHROMAN DERIVATIVES | HATZENBUHLER NICOLE T | 2007-08-16 | — | — | US | disclosed |
| US-20070191417-A1 | QUINOLINE 3-AMINO CHROMAN DERIVATIVES | HATZENBUHLER NICOLE T | 2007-08-16 | — | — | US | disclosed |
| US-20070191417-A1 | QUINOLINE 3-AMINO CHROMAN DERIVATIVES | HATZENBUHLER NICOLE T | 2007-08-16 | — | — | US | disclosed |
| US-7227023-B2 | Quinoline 3-amino chroman derivatives | WYETH (US) | 2007-06-05 | — | — | US | disclosed |
| US-7227023-B2 | Quinoline 3-amino chroman derivatives | WYETH (US) | 2007-06-05 | — | — | US | disclosed |
| US-7227023-B2 | Quinoline 3-amino chroman derivatives | WYETH (US) | 2007-06-05 | — | — | US | disclosed |
| CN-1809574-A | Quinoline 3-amino chroman derivatives | WYETH CORP (US) | 2006-07-26 | — | — | CN | disclosed |
| EP-1638976-A1 | QUINOLINE 3-AMINO CHROMAN DERIVATIVES | Wyeth (US) | 2006-03-29 | — | — | EP | disclosed |
| US-20050004157-A1 | Quinoline 3-amino chroman derivatives | WYETH | 2005-01-06 | — | — | US | disclosed |
| WO-2004099214-A1 | QUINOLINE 3-AMINO CHROMAN DERIVATIVES | WYETH (US) | 2004-11-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170354650-A1 | QUINOLINE DERIVATIVES FOR INHIBITING HISTONE METHYLTRANSFERASES AND USE THEREOF | NSD1, EHMT1, SETDB1 | SETDB1 3/4885CYP3A4 3799/4885CYP2A6 4751/4885 |
| US-20070191417-A1 | QUINOLINE 3-AMINO CHROMAN DERIVATIVES | HTR3C, HTR3A, HTR2C | SETDB1 3606/4885CYP3A4 155/4885CYP2A6 693/4885 |
| US-20050004157-A1 | Quinoline 3-amino chroman derivatives | HTR3C, HTR3A, HTR2C | SETDB1 3606/4885CYP3A4 155/4885CYP2A6 693/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.