Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNMT1 | P26358 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | MTOR | P42345 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.43 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.43 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.43 |
| ▸ | GMNN | O75496 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | THPO | P40225 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | HBB | P68871 | 1/20 | 0.43 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4418542 | 0.88 | LMNA (0.56) | DNMT1LMNAMTORALDH1A1THRB | |
| SCHEMBL2583348 | 0.88 | LMNA (0.56) | DNMT1LMNAMTORALDH1A1THRB | |
| SCHEMBL4418541 | 0.88 | LMNA (0.56) | DNMT1LMNAMTORALDH1A1THRB | |
| SCHEMBL11332590 | 0.88 | LMNA (0.56) | DNMT1LMNAMTORALDH1A1THRB | |
| SCHEMBL2338693 | 0.83 | LMNA (0.46) | DNMT1LMNAMTORALDH1A1THRB | |
| SCHEMBL5697563 | 0.83 | LMNA (0.46) | DNMT1LMNAMTORALDH1A1THRB | |
| SCHEMBL7194470 | 0.83 | LMNA (0.46) | DNMT1LMNAMTORALDH1A1THRB | |
| SCHEMBL28077035 | 0.83 | LMNA (0.46) | DNMT1LMNAMTORALDH1A1THRB | |
| SCHEMBL2582377 | 0.82 | DNMT1 (0.40) | DNMT1LMNAMTORALDH1A1THRB | |
| SCHEMBL25279627 | 0.79 | LMNA (0.46) | DNMT1LMNAMTORALDH1A1THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070232798-A1 | Process For The Synthesis Of 2'-O-Substituted Pyrimidines And Oligomeric Compounds Therefrom | COOK PHILLIP D | 2007-10-04 | — | — | US | disclosed |
| US-20050059815-A1 | Processes for the synthesis of 2'-O-substituted pyrimidines and oligomeric compounds therefrom | COOK PHILLIP DAN (US) | 2005-03-17 | — | — | US | disclosed |
| US-6642367-B2 | Oligonucleotide sfor use in the treatment of cancer and viral diseases | ISIS PHARMACEUTICALS, INC. | 2003-11-04 | — | — | US | disclosed |
| US-20030050454-A1 | Process for the synthesis of 2' -O-substituted pyrimidines and oligomeric compounds therefrom | ISIS PHARMACEUTICALS, INC. | 2003-03-13 | — | — | US | disclosed |
| US-6222025-B1 | OLIGONUCLEOTIDES HAVING 2' AND 5 SUBSTITUTED PYRIMIDINE NUCLEOTIDES; INCREASED AFFINITY FOR NUCLEIC ACIDS; INCREASED NUCLEASE RESISTANCE | ISIS PHARMACEUTICALS, INC. | 2001-04-24 | — | — | US | disclosed |
| US-6166197-A | Oligomeric compounds having pyrimidine nucleotide (S) with 2'and 5 substitutions | ISIS PHARMACEUTICALS, INC. (US) | 2000-12-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050059815-A1 | Processes for the synthesis of 2'-O-substituted pyrimidines and oligomeric compounds therefrom | NUDT1, DPYD, UMPS | DNMT1 101/4885LMNA 3765/4885MTOR 4149/4885 |
| US-20070232798-A1 | Process For The Synthesis Of 2'-O-Substituted Pyrimidines And Oligomeric Compounds Therefrom | TYMS, RRM2, ATIC | DNMT1 154/4885LMNA 3653/4885MTOR 3991/4885 |
| US-20030050454-A1 | Process for the synthesis of 2' -O-substituted pyrimidines and oligomeric compounds therefrom | ATIC, TYMS, RRM2 | DNMT1 192/4885LMNA 3797/4885MTOR 4007/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.