Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A known ✓ | P08908 | 1/20 | 0.44 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.44 |
| ▸ | KCNH2 known ✓ | Q12809 | 2/20 | 0.43 |
| ▸ | DRD2 known ✓ | P14416 | 2/20 | 0.42 |
| ▸ | ADRB2 known ✓ | P07550 | 2/20 | 0.41 |
| ▸ | ADRB1 known ✓ | P08588 | 2/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 5/20 | 0.42 |
| ▸ | DRD4 | P21917 | 2/20 | 0.42 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL5584951 | 1.00 | HTR1A (0.44) | HTR1ASLC6A4KCNH2ABCB1DRD2 | |
| SCHEMBL14571531 | 0.95 | HTR1A (0.47) | HTR1ASLC6A4KCNH2ABCB1DRD2 | |
| SCHEMBL5584821 | 0.91 | HTR1A (0.47) | HTR1ASLC6A4KCNH2DRD2DRD4 | |
| Fumaric Acid SCHEMBL5584136 | 0.86 | HTR1A (0.48) | HTR1ASLC6A4KCNH2ABCB1DRD2 | |
| Maleic Acid SCHEMBL5584135 | 0.86 | HTR1A (0.48) | HTR1ASLC6A4KCNH2ABCB1DRD2 | |
| SCHEMBL5584673 | 0.80 | HTR1A (0.51) | HTR1ASLC6A4KCNH2ABCB1DRD2 | |
| SCHEMBL5584396 | 0.78 | DRD4 (0.51) | HTR1ASLC6A4KCNH2DRD2DRD4 | |
| SCHEMBL14571534 | 0.76 | HTR1A (0.49) | HTR1ASLC6A4KCNH2DRD2DRD4 | |
| SCHEMBL5584333 | 0.76 | HTR1A (0.51) | HTR1ASLC6A4DRD2DRD4ADRB2 | |
| SCHEMBL5584319 | 0.76 | KCNH2 (0.51) | HTR1ASLC6A4KCNH2ABCB1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7196199-B2 | Antiserotonine agents; antidepressants | MITSUBISHI PHARMA CORPORATION (JP) | 2007-03-27 | — | — | US | disclosed |
| EP-1188747-B1 | PHENOXYPROPYLAMINE COMPOUNDS | MITSUBISHI PHARMA CORP (JP) | 2005-09-07 | — | — | EP | disclosed |
| US-20040138227-A1 | Phenoxypropylamine compounds | NISHIYAMA AKIRA | 2004-07-15 | — | — | US | disclosed |
| US-6720320-B2 | ANTISEROTONINE AGENTS | MITSUBISHI PHARMA CORPORATION (JP) | 2004-04-13 | — | — | US | disclosed |
| US-20020111358-A1 | Phenoxypropylamine compounds | MITSUBISHI PHARMA CORPORATION (JP) | 2002-08-15 | — | — | US | disclosed |
| EP-1188747-A1 | PHENOXYPROPYLAMINE COMPOUNDS | Mitsubishi Pharma Corporation (JP) | 2002-03-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040138227-A1 | Phenoxypropylamine compounds | HTR1A, HTR1D, HTR5A | HTR1A 1/4885SLC6A4 10/4885KCNH2 251/4885 |
| US-20020111358-A1 | Phenoxypropylamine compounds | HTR1A, HTR1D, HTR5A | HTR1A 1/4885SLC6A4 10/4885KCNH2 251/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.