Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.35 |
| ▸ | RAB9A | P51151 | 4/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | PKM | P14618 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 3/20 | 0.33 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.32 |
| ▸ | RELA | Q04206 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5583652 | 0.83 | ENPP3 (0.40) | NPC1RAB9ASMN1; SMN2ALOX15ALOX12 | |
| SCHEMBL5586547 | 0.79 | MEN1 (0.36) | MAPTSMN1; SMN2ADORA3MEN1KMT2A | |
| SCHEMBL4597327 | 0.79 | DRD2 (0.47) | RAB9ASMN1; SMN2POLBDRD2HTR7 | |
| SCHEMBL5583422 | 0.76 | CNR2 (0.33) | DRD2 | |
| SCHEMBL5583557 | 0.73 | HTR1A (0.44) | NPC1RAB9ASMN1; SMN2TP53HTR7 | |
| SCHEMBL5586539 | 0.73 | HTR1A (0.44) | MAPTSMN1; SMN2LMNATP53HTR7 | |
| SCHEMBL14278982 | 0.72 | PARP1 (0.44) | NPC1RAB9AMAPTPKMSMN1; SMN2 | |
| SCHEMBL5583665 | 0.72 | CYP11B1 (0.47) | RAB9AMAPTSMN1; SMN2LMNATP53 | |
| SCHEMBL4596910 | 0.71 | PARP1 (0.49) | DRD2HTR7 | |
| SCHEMBL5586507 | 0.71 | HTR1A (0.47) | MAPTSMN1; SMN2POLBDRD2HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007509174-A | — | — | 2007-04-12 | — | — | JP | claimed |
| EP-1675840-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | Wyeth a Corporation of the State of Delaware (US) | 2006-07-05 | — | — | EP | claimed |
| WO-2005044812-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | WYETH A CORPORATION OF THE STATE OF DELAWARE (US) | 2005-05-19 | — | — | WO | claimed |