Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | DRD3 | P35462 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.38 |
| ▸ | HTR1A | P08908 | 3/20 | 0.38 |
| ▸ | NCF1 | P14598 | 1/20 | 0.37 |
| ▸ | BRD9 | Q9H8M2 | 5/20 | 0.36 |
| ▸ | BRD4 | O60885 | 2/20 | 0.36 |
| ▸ | BRPF1 | P55201 | 2/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.34 |
| ▸ | BRD7 | Q9NPI1 | 2/20 | 0.34 |
| ▸ | GNRHR | P30968 | 2/20 | 0.34 |
| ▸ | HTR3A | P46098 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5599213 | 0.86 | SLC6A2 (0.40) | DRD2DRD3SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL5592191 | 0.85 | HSD11B1 (0.36) | DRD2DRD3KCNH2HSD11B1 | |
| SCHEMBL5592378 | 0.85 | HSD11B1 (0.37) | DRD2DRD3KCNH2SLC6A2SLC6A4 | |
| SCHEMBL5592316 | 0.83 | DRD2 (0.37) | DRD2DRD3KCNH2SLC6A2SLC6A4 | |
| SCHEMBL5592325 | 0.82 | NCF1 (0.36) | DRD2DRD3SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL5592318 | 0.82 | MEN1 (0.36) | DRD2DRD3SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL5592172 | 0.82 | DRD2 (0.42) | DRD2DRD3KCNH2SLC6A2SLC6A4 | |
| SCHEMBL5611716 | 0.80 | DRD2 (0.39) | DRD2DRD3KCNH2SLC6A2SLC6A4 | |
| SCHEMBL5592512 | 0.80 | DRD2 (0.39) | DRD2DRD3KCNH2SLC6A2SLC6A4 | |
| SCHEMBL5592486 | 0.80 | DRD2 (0.39) | DRD2DRD3KCNH2SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007057742-A2 | NOVEL PIPERAZINONE DERIVATIVES | PFIZER PRODUCTS INC. (US) | 2007-05-24 | — | — | WO | disclosed |