Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 3/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 6/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.36 |
| ▸ | ELANE | P08246 | 2/20 | 0.35 |
| ▸ | CHIA | Q9BZP6 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5592307 | 0.85 | HSD11B1 (0.36) | HSD11B1TRPV1TRPA1KCNH2TRPM8 | |
| SCHEMBL5592389 | 0.85 | DRD2 (0.39) | HSD11B1KCNH2DRD2DRD3 | |
| SCHEMBL5166623 | 0.84 | ROCK2 (0.40) | HSD11B1TRPV1TRPA1KCNH2TRPM8 | |
| SCHEMBL5592384 | 0.83 | CHIA (0.35) | ELANECHIADRD2DRD3 | |
| SCHEMBL5599159 | 0.83 | ELANE (0.35) | ELANECHIA | |
| SCHEMBL5592320 | 0.83 | CHIA (0.39) | HSD11B1TRPV1TRPA1KCNH2TRPM8 | |
| SCHEMBL5165708 | 0.82 | FPR2 (0.40) | HSD11B1TRPV1TRPA1KCNH2TRPM8 | |
| SCHEMBL5592285 | 0.82 | ELANE (0.35) | ELANECHIA | |
| SCHEMBL5163927 | 0.77 | ROCK2 (0.39) | TRPV1ELANECHIA | |
| SCHEMBL5167396 | 0.76 | FPR2 (0.43) | HSD11B1TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007057742-A2 | NOVEL PIPERAZINONE DERIVATIVES | PFIZER PRODUCTS INC. (US) | 2007-05-24 | — | — | WO | disclosed |