SCHEMBL5597215

SCHEMBL5597215

Cc1ccc(O)c(-n2ncc(-c3ccccc3)n2)c1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 5/20 0.57
RAB9A P51151 5/20 0.57
LMNA P02545 1/20 0.57
MEN1 O00255 3/20 0.42
KMT2A Q03164 3/20 0.42
TP53 P04637 1/20 0.42
MAPT P10636 7/20 0.38
KDM4E B2RXH2 4/20 0.38
L3MBTL1 Q9Y468 2/20 0.38
MAPK1 P28482 1/20 0.38
NPSR1 Q6W5P4 1/20 0.38
HPGD P15428 3/20 0.37
HTT P42858 2/20 0.37
GRM5 P41594 2/20 0.36
ALDH1A1 P00352 4/20 0.36
HSD17B10 Q99714 1/20 0.36
TDP1 Q9NUW8 1/20 0.36
SMN1; SMN2 Q16637 2/20 0.35
GAA P10253 1/20 0.35
POLB P06746 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5138027 0.82 MAPT (0.44) NPC1RAB9ALMNAMEN1KMT2A
SCHEMBL28434913 0.75 RAB9A (0.48) NPC1RAB9ALMNAMEN1KMT2A
SCHEMBL3339587 0.74 RAB9A (0.36) NPC1RAB9ALMNAMEN1KMT2A
Drometrizole SCHEMBL15616 0.73 NPC1 (1.00) NPC1RAB9ALMNAMEN1KMT2A
Drometrizole SCHEMBL2548258 0.73 NPC1 (1.00) NPC1RAB9ALMNAMEN1KMT2A
Drometrizole SCHEMBL29350665 0.73 NPC1 (1.00) NPC1RAB9ALMNAMEN1KMT2A
Drometrizole SCHEMBL27755727 0.73 NPC1 (1.00) NPC1RAB9ALMNAMEN1KMT2A
SCHEMBL28375928 0.73 NPC1 (0.73) NPC1RAB9ALMNAMEN1KMT2A
SCHEMBL28375372 0.73 NPC1 (0.73) NPC1RAB9ALMNAMEN1KMT2A
SCHEMBL8495708 0.72 SOAT2 (0.38) NPC1RAB9ATP53MAPTSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-6272018-A None JP disclosed
EP-1756673-A1 DEVELOPER FOR A PHOTOPOLYMER PROTECTIVE LAYER E.I.Du pont de nemours and company (US) 2007-02-28 EP disclosed
US-20050282094-A1 Developer for a photopolymer protective layer E. I. DU PONT DE NEMOURS AND COMPANY 2005-12-22 US disclosed
WO-2005119372-A1 DEVELOPER FOR A PHOTOPOLYMER PROTECTIVE LAYER E.I. DUPONT DE NEMOURS AND COMPANY (US) 2005-12-15 WO disclosed
EP-0646038-B1 PASSIVATED AND STABILIZED POROUS SUPPORTS AND METHODS FOR THE PREPARATION AND USE OF SAME LIFE TECHNOLOGIES INC (US) 2000-11-15 EP disclosed
US-6045697-A PREVENTING NON-SPECIFIC INTERACTIONS BETWEEN PROTEINS ETC. AND THE CHROMATOGRAPHIC SUPPORT BY FILLING THE MATRIX PORES WITH A POLYMER GEL TO FORM A RECEPTIVE THREE-DIMENSIONAL POLYMER NETWORK DEACTIVATING INNATE SUPPORT SURFACE GROUPS LIFE TECHNOLOGIES, INC. (US) 2000-04-04 US disclosed
US-5906734-A COMPOSITE CHROMATOGRAPHY MEDIUM COMPRISING SUBSTRATE IMPREGNATED WITH POLYMERIZED CROSSLINKED BLEND WHICH FORMS SURFACE BARRIER LAYER AND PORE-FILLING GEL; REVERSIBLE SORPTION, SELECTIVITY BIOSEPRA INC. (US) 1999-05-25 US disclosed
US-5672276-A CHROMATOGRAPHY SEPARATION BIOSEPRA INC. (US) 1997-09-30 US disclosed
WO-1996025992-A9 PASSIVATED POROUS POLYMER SUPPORTS AND METHODS FOR THE PREPARATION AND USE OF SAME 1997-01-16 WO disclosed
US-5593576-A CHROMATOGRAPHY BIOSEPRA, INC. (US) 1997-01-14 US disclosed
WO-1996025992-A1 PASSIVATED POROUS POLYMER SUPPORTS AND METHODS FOR THE PREPARATION AND USE OF SAME BIOSEPRA, INC. (US) 1996-08-29 WO disclosed
US-5470463-A Passivation mixture comprising three-dimensional polymers from main and neutralizing monomers and crosslinking agent; eliminates undesirable interactions with biomolecules SEPRACOR INC. (US) 1995-11-28 US disclosed
US-5445732-A Eliminates undesirable non-specific interaction with biomolecules SEPRACOR INC. (US) 1995-08-29 US disclosed
EP-0646038-A4 PASSIVATED AND STABILIZED POROUS SUPPORTS AND METHODS FOR THE PREPARATION AND USE OF SAME. SEPRACOR INC (US) 1995-06-28 EP disclosed
EP-0646038-A1 PASSIVATED AND STABILIZED POROUS SUPPORTS AND METHODS FOR THE PREPARATION AND USE OF SAME SEPRACOR, INC. (US) 1995-04-05 EP disclosed
US-5393430-A Chromatographic separation of proteins using cationic and anionic exchange resins SEPRACOR, INC. (US) 1995-02-28 US disclosed
JP-H06272018-A LAMINATED FILM OIKE IND CO LTD 1994-09-27 JP disclosed
WO-1994000214-A1 PASSIVATED AND STABILIZED POROUS SUPPORTS AND METHODS FOR THE PREPARATION AND USE OF SAME SEPRACOR INC. (US) 1994-01-06 WO disclosed
US-5268097-A Silica matrix covered with hydrophobic polystyrene SEPRACOR INC. (US) 1993-12-07 US disclosed