Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 2/20 | 0.39 |
| ▸ | HTR7 | P34969 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13724185 | 0.81 | MAPT (0.47) | KDM4ETP53ALDH1A1MAPTMAPK1 | |
| SCHEMBL28083181 | 0.81 | ADRB1 (0.60) | ALDH1A1LMNAHTTGFERHPGD | |
| SCHEMBL7358977 | 0.80 | HTR3E (0.57) | ALDH1A1MAPTMAPK1LMNANPC1 | |
| SCHEMBL7354505 | 0.77 | ADRB2 (0.60) | ALDH1A1TSHRADRB1 | |
| SCHEMBL2107593 | 0.77 | ADRB1 (0.64) | ALDH1A1MAPTLMNANPC1RAB9A | |
| SCHEMBL894537 | 0.75 | ADRB1 (0.63) | KDM4ETP53ALDH1A1MAPTMAPK1 | |
| SCHEMBL233425 | 0.75 | ADRB1 (0.63) | KDM4ETP53ALDH1A1MAPTMAPK1 | |
| Hydrochloric Acid SCHEMBL714521 | 0.74 | ADRB1 (0.61) | KDM4ETP53ALDH1A1MAPTMAPK1 | |
| Bromide SCHEMBL10674981 | 0.74 | ADRB1 (0.61) | KDM4ETP53ALDH1A1MAPTMAPK1 | |
| Hydrochloric Acid SCHEMBL1005870 | 0.74 | ADRB1 (0.61) | KDM4ETP53ALDH1A1MAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1982001186-A1 | NOVEL BENZOXAZOLINONES,SUBSTITUTED IN THE 6-POSITION BY AN AMINOALCOHOL CHAIN OR AMINO-KETONE CHAIN,THEIR PREPARATION AND THEIR USE IN PHARMACEUTICAL PREPARATIONS | BUSCH N | 1982-04-15 | — | — | WO | claimed |
| WO-2018112077-A1 | INHIBITORS OF DIHYDROCERAMIDE DESATURASE FOR TREATING DISEASE | CENTAURUS THERAPEUTICS (US) | 2018-06-21 | — | — | WO | disclosed |
| EP-1268412-B8 | SULPHONAMIDO-SUBSTITUTED BRIDGED BICYCLOALKYL DERIVATIVES | MERCK SHARP & DOHME (GB) | 2007-02-21 | — | — | EP | disclosed |
| EP-1268412-A1 | SULPHONAMIDO-SUBSTITUTED BRIDGED BICYCLOALKYL DERIVATIVES | MERCK SHARP & DOHME LTD. (GB) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001070677-A1 | SULPHONAMIDO-SUBSTITUTED BRIDGED BICYCLOALKYL DERIVATIVES | MERCK SHARP & DOHME LIMITED (GB) | 2001-09-27 | — | — | WO | disclosed |