Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.53 |
| ▸ | DRD4 | P21917 | 4/20 | 0.53 |
| ▸ | DRD3 | P35462 | 4/20 | 0.53 |
| ▸ | CHRM2 | P08172 | 13/20 | 0.48 |
| ▸ | CHRM3 | P20309 | 13/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28941485 | 0.83 | CHRM2 (0.52) | DRD2CHRM2CHRM3OPRM1SIGMAR1 | |
| SCHEMBL27584816 | 0.81 | HCAR2 (0.37) | DRD2DRD4DRD3KMT2A | |
| SCHEMBL5597755 | 0.76 | DRD2 (0.42) | DRD2DRD4DRD3MEN1KMT2A | |
| SCHEMBL5597759 | 0.73 | FAAH (0.56) | DRD2DRD4DRD3 | |
| SCHEMBL5597868 | 0.73 | DRD4 (0.60) | DRD2DRD4DRD3SIGMAR1KMT2A | |
| SCHEMBL2930230 | 0.72 | DRD2 (0.72) | DRD2DRD4DRD3SIGMAR1MEN1 | |
| SCHEMBL27584819 | 0.72 | L3MBTL1 (0.38) | CHRM2CHRM3OPRM1MEN1KMT2A | |
| SCHEMBL30006056 | 0.70 | CHRM3 (0.53) | CHRM2CHRM3OPRM1SIGMAR1MEN1 | |
| SCHEMBL27092754 | 0.70 | CHRM3 (0.53) | CHRM2CHRM3OPRM1SIGMAR1MEN1 | |
| SCHEMBL3325625 | 0.69 | CHRM2 (0.56) | DRD2CHRM2CHRM3OPRM1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1379668-A | 3(5)-ureido-pyrazole derivatives, process for their preparation and their use as antitumor agents | PHARMACIA & UPJOHN SPA (IT) | 2002-11-13 | — | — | CN | claimed |
| EP-1202734-B1 | 3(5)-UREIDO-PYRAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS | PFIZER ITALIA SRL (IT) | 2007-05-02 | — | — | EP | disclosed |
| EP-1202734-A4 | 3(5)-UREIDO-PYRAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS | PHARMACIA ITALIA SPA (IT) | 2004-09-01 | — | — | EP | disclosed |
| CN-1379668-A | 3(5)-ureido-pyrazole derivatives, process for their preparation and their use as antitumor agents | PHARMACIA & UPJOHN SPA (IT) | 2002-11-13 | — | — | CN | disclosed |
| US-6387900-B1 | ANTICANCER AGENTS | PHARMACIA & UPJOHN S.P.A. (IT) | 2002-05-14 | — | — | US | disclosed |
| EP-1202734-A1 | 3(5)-UREIDO-PYRAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS | Pharmacia Italia S.p.A. (IT) | 2002-05-08 | — | — | EP | disclosed |
| WO-2001012188-A1 | 3(5)-UREIDO-PYRAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS | PHARMACIA & UPJOHN S.P.A. (IT) | 2001-02-22 | — | — | WO | disclosed |