Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.45 |
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5598235 | 0.91 | MAPT (0.59) | MAPTALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL5591514 | 0.84 | ALDH1A1 (0.48) | MAPTALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL5609833 | 0.82 | LMNA (0.42) | MAPTALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL1532381 | 0.78 | ALDH1A1 (0.57) | MAPTALDH1A1MEN1KMT2APOLB | |
| SCHEMBL5005578 | 0.76 | SIRT6 (0.61) | MAPTALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL2712073 | 0.76 | SLC6A9 (0.50) | MAPTALDH1A1MEN1KMT2AMAPK1 | |
| SCHEMBL15961228 | 0.75 | SIRT6 (0.59) | MAPTALDH1A1LMNAKMT2AMAPK1 | |
| SCHEMBL17542589 | 0.75 | MAPT (0.48) | MAPTALDH1A1MEN1KMT2AMAPK1 | |
| SCHEMBL16396072 | 0.74 | MAPT (0.57) | MAPTALDH1A1LMNAMAPK1SMN1; SMN2 | |
| SCHEMBL19398204 | 0.74 | MAPT (0.57) | MAPTALDH1A1LMNAKMT2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007072041-A1 | THERAPEUTIC COMPOUNDS | ASTEX THERAPEUTICS LIMITED (GB) | 2007-06-28 | — | — | WO | disclosed |