Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.40 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.38 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.38 |
| ▸ | JAK1 | P23458 | 3/20 | 0.37 |
| ▸ | JAK2 | O60674 | 2/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.37 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5598468 | 0.79 | TP53 (0.48) | TP53MEN1KMT2ARPS6KB1NPC1 | |
| SCHEMBL5598237 | 0.79 | TP53 (0.48) | TP53MEN1KMT2ARPS6KB1NPC1 | |
| SCHEMBL6171265 | 0.79 | TP53 (0.48) | TP53MEN1KMT2ARPS6KB1NPC1 | |
| SCHEMBL6072932 | 0.77 | TP53 (0.46) | TP53MEN1KMT2ARPS6KB1NPC1 | |
| SCHEMBL6170527 | 0.74 | TP53 (0.42) | TP53MEN1KMT2ARPS6KB1NPC1 | |
| SCHEMBL5598180 | 0.71 | HTR1E (0.42) | TP53MEN1KMT2ARPS6KB1NPC1 | |
| SCHEMBL28110193 | 0.70 | KDM4E (0.39) | TP53NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL28037679 | 0.70 | IRAK4 (0.39) | TP53MEN1KMT2ANPC1HTT | |
| SCHEMBL959762 | 0.70 | SLC6A3 (0.58) | MEN1KMT2ASLC6A3LMNA | |
| SCHEMBL13124077 | 0.70 | SLC6A3 (0.58) | MEN1KMT2ASLC6A3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1763353-A1 | COMBINATION THERAPIES UTILIZING BENZAMIDE INHIBITORS OF THE P2X<sb>7</sb> RECEPTOR | Warner-Lambert Company LLC (US) | 2007-03-21 | — | — | EP | disclosed |
| WO-2006003517-A1 | COMBINATION THERAPIES UTILIZING BENZAMIDE INHIBITORS OF THE P2X7 RECEPTOR | WARNER-LAMBERT COMPANY LLC (US) | 2006-01-12 | — | — | WO | disclosed |