Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.41 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.41 |
| ▸ | METAP2 | P50579 | 4/20 | 0.40 |
| ▸ | METAP1 | P53582 | 2/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.40 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.40 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.40 |
| ▸ | DHODH | Q02127 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5598468 | 1.00 | TP53 (0.48) | TP53NPC1MEN1KMT2ASIRT2 | |
| SCHEMBL6171265 | 1.00 | TP53 (0.48) | TP53NPC1MEN1KMT2ASIRT2 | |
| SCHEMBL6170527 | 0.95 | TP53 (0.42) | TP53NPC1MEN1KMT2ASIRT2 | |
| SCHEMBL6072932 | 0.82 | TP53 (0.46) | TP53NPC1MEN1KMT2ASIRT2 | |
| SCHEMBL3720389 | 0.80 | ALDH1A1 (0.44) | MEN1KMT2AKDM4EALDH1A1HPGD | |
| SCHEMBL5598341 | 0.79 | TP53 (0.44) | TP53NPC1MEN1KMT2ASIRT2 | |
| SCHEMBL5598180 | 0.76 | HTR1E (0.42) | TP53NPC1MEN1KMT2ARPS6KB1 | |
| SCHEMBL5171003 | 0.75 | TP53 (0.40) | TP53MEN1KMT2AMETAP2METAP1 | |
| SCHEMBL28064364 | 0.74 | GABRA1 (0.42) | NPC1MEN1KMT2AMETAP2DHODH | |
| SCHEMBL8036927 | 0.74 | GABRA1 (0.42) | NPC1MEN1KMT2AMETAP2DHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1763353-A1 | COMBINATION THERAPIES UTILIZING BENZAMIDE INHIBITORS OF THE P2X<sb>7</sb> RECEPTOR | Warner-Lambert Company LLC (US) | 2007-03-21 | — | — | EP | disclosed |
| WO-2006003517-A1 | COMBINATION THERAPIES UTILIZING BENZAMIDE INHIBITORS OF THE P2X7 RECEPTOR | WARNER-LAMBERT COMPANY LLC (US) | 2006-01-12 | — | — | WO | disclosed |
| EP-1581232-A1 | 3-(3,5-DIOXO-4,5-DIHYDRO-3H-(1,2,4)TRIAZIN-2-YL)-BENZAMIDE DERIVATIVES AS P2X7-INHIBITORS FOR THE TREATMENT OF INFLAMMATORY DISEASES | Pfizer Products Inc. (US) | 2005-10-05 | — | — | EP | disclosed |
| EP-1581507-A1 | BENZAMIDE INHIBITORS OF THE P2X7 RECEPTOR | Pfizer Products Inc. (US) | 2005-10-05 | — | — | EP | disclosed |
| WO-2004058731-A1 | BENZAMIDE INHIBITORS OF THE P2X7 RECEPTOR | PFIZER PRODUCTS INC. (US) | 2004-07-15 | — | — | WO | disclosed |
| WO-2004058270-A1 | 3-(3,5-DIOXO-4,5-DIHYDRO-3H-(1,2,4)TRIAZIN-2-YL)-BENZAMIDE DERIVATIVES AS P2X7-INHIBITORS FOR THE TREATMENT OF INFLAMMATORY DISEASES | PFIZER PRODUCTS INC. (US) | 2004-07-15 | — | — | WO | disclosed |