SCHEMBL5599079

SCHEMBL5599079

CN(C)C(Cl)CCOc1ccc(Cc2nccn2C)cc1

nearest known ligand 0.42

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 3/20 0.42
MEN1 O00255 2/20 0.42
CHRNB2 P17787 1/20 0.41
CHRNA4 P43681 1/20 0.41
LTA4H P09960 4/20 0.36
L3MBTL1 Q9Y468 3/20 0.34
HPGD P15428 1/20 0.34
CNR2 P34972 5/20 0.34
MAPT P10636 2/20 0.33
LMNA P02545 1/20 0.33
MAPK1 P28482 1/20 0.33
HTT P42858 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
BCHE P06276 1/20 0.33
CNR1 P21554 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5601407 0.88 MEN1 (0.44) KMT2AMEN1CHRNB2CHRNA4LTA4H
SCHEMBL5601238 0.86 POLB (0.39) KMT2AMEN1CHRNB2CHRNA4LTA4H
SCHEMBL5601356 0.85 CHRNB2 (0.39) KMT2AMEN1CHRNB2CHRNA4LTA4H
SCHEMBL5599425 0.79 PSMB1 (0.43) KMT2AMEN1LTA4H
SCHEMBL5600396 0.74 POLB (0.40) KMT2AMEN1MAPTLMNA
SCHEMBL6650451 0.73 LMNA (0.39) KMT2AMEN1CHRNB2CHRNA4LTA4H
SCHEMBL6654163 0.71 HRH3 (0.35) KMT2AMEN1CHRNB2CHRNA4L3MBTL1
SCHEMBL6650689 0.71 L3MBTL1 (0.40) KMT2AMEN1L3MBTL1MAPTLMNA
SCHEMBL5599549 0.71 L3MBTL1 (0.42) KMT2AMEN1CHRNB2CHRNA4L3MBTL1
SCHEMBL6648700 0.71 HRH3 (0.35) KMT2AMEN1CHRNB2CHRNA4CNR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1103243-B1 UTILIZATION OF ARYL(OR HETEROARYL)AZOLYLCARBINOL DERIVATIVES FOR THE TREATMENT OF TROUBLES MEDIATED BY AN EXCESS OF SUBSTANCE P ESTEVE LABOR DR (ES) 2004-01-07 EP claimed
EP-1755678-A2 ACTIVE SUBSTANCE COMBINATION OF A CARBINOL COMPOUND AND AN OPIOID LABORATORIOS DEL DR. ESTEVE, S.A. (ES) 2007-02-28 EP disclosed
WO-2005097192-A2 ACTIVE SUBSTANCE COMBINATION OF A CARBINOL COMPOUND AND AN OPIOID LABORATORIOS DEL DR. ESTEVE, S.A. (ES) 2005-10-20 WO disclosed