Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | FUCA1 | P04066 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5781699 | 1.00 | GLA (0.39) | GLAALDH1A1LMNAPOLBMAPT | |
| SCHEMBL5599710 | 0.76 | GLA (0.37) | GLAALDH1A1LMNAPOLBMAPT | |
| SCHEMBL5599793 | 0.75 | LMNA (0.44) | ALDH1A1LMNAPOLBMAPTKMT2A | |
| SCHEMBL5599670 | 0.70 | CYP2C19 (0.44) | ALDH1A1MAPTNPC1KMT2ASMN1; SMN2 | |
| SCHEMBL5783811 | 0.70 | HTT (0.36) | LMNAHTTTP53 | |
| SCHEMBL5599482 | 0.69 | HTT (0.37) | ALDH1A1LMNAHTTKMT2ASMN1; SMN2 | |
| SCHEMBL5784794 | 0.69 | RXFP1 (0.42) | KMT2ATP53 | |
| SCHEMBL5599667 | 0.69 | ATM (0.37) | HTTATMSMN1; SMN2 | |
| SCHEMBL5599757 | 0.69 | SIGMAR1 (0.40) | ALDH1A1LMNAMAPTHTTSMN1; SMN2 | |
| SCHEMBL5578568 | 0.67 | NOTUM (0.43) | GLAALDH1A1LMNAPOLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005063745-A9 | NOVEL SPIROINDOLINE OR SPIROISOQUINOLINE COMPOUNDS, METHODS OF USE AND COMPOSITIONS THEREOF | ARENA PHARM INC (US) | 2007-02-01 | — | — | WO | claimed |